›› 2011, Vol. 42 ›› Issue (6): 854-858.doi: 10.3969/j.issn.0529-1356.2011.06.028

• 生物工程学 • 上一篇    下一篇

下颌骨髁突支架的个体化设计与初步构建

王君玲1,3;陈艳玲2,3; 李文生1,2,3 *   

  1. 1.复旦大学上海医学院人体解剖学与组织学胚胎学系; 2.数字医学研究中心;3.上海市医学图像处理与计算机辅助手术重点实验室,上海 200032
  • 收稿日期:2011-06-23 修回日期:2011-07-05 出版日期:2011-12-06
  • 通讯作者: 李文生

Custom design and primary construction of the mandibular condyle scaffold

  1. 1.Department of Human Anatomy and Histoembryology; 2.Digital Medical Research Center; 3.Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Shanghai Medical College of Fudan University, Shanghai 200032,China
  • Received:2011-06-23 Revised:2011-07-05 Online:2011-12-06
  • Contact: LI Wen-sheng

关键词: 下颌骨髁突, 组织工程支架, 快速成型技术, 逆向工程,

Abstract: Objective To explore the method of designing and manufacturing the mandibular condyle scaffold individually by rapid prototyping technologies and reverse engineering.Methods Cranial CT image data were processed in Mimics software for reconstruction of one side of ramus of mandible, and were inputted into Solidworks software to edit by the format of stl. A negative mold of the mandibular condyle scaffold was obtained. The mold was fabricated by resin materials utilizing rapid prototyping. Biomaterials were filled into the resin mold. When the materials were cured, we eliminated the resin mold and acquired a multi-pores three dimensional mandibular condyle scaffold model. The general morphology and microstructure of the scaffold model were observed by scanning electron microscopy (SEM). Results The mandibular condyle scaffold made of biomaterials was accordance with the one our computer designed. SEM observation revealed that the model was made of collagen in the cartilage-like layer and calcium phosphate cement/poly (lactic- co-glycolic acid) in the bone-like layer. Conclusion It is feasible to fabricate mandibular condyle scaffold individually by using reverse engineering and rapid prototyping technology.

Key words: Mandibular condyle, Tissue engineering scaffold, Rapid prototyping, Reverse engineering, Human

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