AAS ›› 2015, Vol. 46 ›› Issue (6): 857-861.doi: 10.16098/j.issn.0529-1356.2015.06.023

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Research on activating transcription factor 6 pathway and its related factors’ regulation on unfolded protein reaction in endoplasmic reticulum stress

XIANG Chun-chen1 HAN Fang 2* SHI Yu-xiu 2*   

  1. 1. China Medical University Clinical Medicine System for Seven Years; 2. China Medical University Department of Histology and Embryology PTSD Laboratory,Shenyang 110013, China
  • Received:2015-04-27 Revised:2015-07-06 Online:2015-12-06 Published:2015-12-06
  • Contact: HAN Fang ;SHI Yu-xiu E-mail:shiyuxiu@163.com

Abstract:

Endoplasmic reticulum stress plays a key role in many diseases’ pathogenesis. Continuous or intense endoplasmic reticulum stress response can induce cell apoptosis. As an endoplasmic reticulum transmembrane protein, activating transcription factor 6(ATF6) can transfer signals to induce unfolded protein response. This review summarizes the ATF6 pathway and its mechanism of regulating apoptosis and pays attention to the related activators and inhibitors, in order to provide background research data for the neurodegenerative disease.

Key words: Endoplasmic reticulum stress, Unfolded protein reaction, Activating transcription factor 6, Activator, Inhibitor