Relationship of body mass index/waist-hip ratio with androgen receptor CAG and GGN repeat polymorphism

doi:10.16098/j.issn.0529-1356.2016.04.017

Abstract

Abstract:

Objective Body mass index (BMI) and waisthip ratio (WHR) are sexually dimorphic. The main reason for the stability of sexual dimorphism of BMI and WHR is the sex-hormone profile of an individual. Variability in testosterone levels has been related to BMI and WHR. At the molecular level, the effect of androgens is mediated through the activation of androgen receptor (AR). The CAG/GGN repeat polymorphisms of the AR gene are associated with AR activity. Thus, we aimed to investigate the effect of CAG/GGN repeat polymorphisms in AR on BMI and WHR in Chinese. Methods BMI was calculated as weight/height squared (kg/m²). WHR was calculated as waist/hip. AR CAG/GGN repeat polymorphisms were genotyped by ABI 3730 DNA analyzer. Results BMI and WHR were different between males and females. The longer GGN allele was positively associated with BMI of females (P<0.03). There was no association between WHR and AR CAG or GGN polymorphisms (all,P>0.05).We did not find any relationship between AR CAG polymorphism and BMI(all,P>0.05). Conclusion The relationship between AR CAG/GGN repeat polymorphisms and BMI/WHR are likely to be more complex than previously appreciated.

Key words: Body mass index, Waist-hip ratio, CAG repeat polymorphism, GGN repeat polymorphism, Direct measurement, Human

ZHANG Chuan LU Hong PEI Li-guo HAO Sheng-ju YAN You-sheng ZHENG Lei DANG Jie HUO Zheng-hao*. Relationship of body mass index/waist-hip ratio with androgen receptor CAG and GGN repeat polymorphism[J]. AAS, 2016, 47(4): 534-538.

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