Regulation of neuroimmune system on learning and memory

doi:10.16098/j.issn.0529-1356.2018.04.022

Abstract

Abstract:

Nervous system and immune system are two main controlling systems for sustaining internal balance of the body, which can mutual regulate each other. The nervous system regulates the immune response of the organism through the nervous and endocrine pathways by releases various cytokines, transmitters and neuropeptides. In turn, immune modulator or neural active substances produced by immune system can regulate the functions of the nervous system. The interaction between the nervous system and the immune system plays an important role in the maintenance and development of the normal function of the nervous system. We review research progress of roles of the immune system include microglia, inflammatory cytokines, especially interleukin (IL)-1β, IL-6, tumor necrosis factor and Toll-like receptors, and peripheral immune system in the normal hippocampal functions such as learning and memory, synaptic transmission, and nerogenesis.

Key words: Microglia, Inflammatory cytokine, Hippocampus, Neurogenesis

DING Yan-ping JIN Yi-ran BAI Yu-jie PAN Zi-yan SHAO Bao-ping. Regulation of neuroimmune system on learning and memory[J]. Acta Anatomica Sinica, 2018, 49(4): 543-548.

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