Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain

doi:10.16098/j.issn.0529-1356.2022.05.002

Acta Anatomica Sinica ›› 2022, Vol. 53 ›› Issue (5): 551-556.doi: 10.16098/j.issn.0529-1356.2022.05.002

Previous Articles Next Articles

Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain

TANG Xiao-lu¹ DENG Cong-cong² WANG Pei¹ CHEN Ming-hui³ TIAN Kai⁴ SU Yan-yan¹ MA Hui⁵ WU Xue-yan^1* SHEN Yu-xian^6,7*

1.Department of Human Anatomy, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China;2.Grade of 2017, Majoring in Clinical Medicine, the Second Clinical Medical College, Anhui Medical University, Hefei 230032, China; 3.Grade of 2017, Majoring in Clinical Medicine, the First Clinical Medical College, Anhui Medical University, Hefei 230032, China; 4.Grade of 2018, Majoring in Clinical Medicine, the Second Clinical Medical College of Anhui Medical University, Hefei 230032, China; 5.Grade of 2016, Majoring in Clinical Medicine, the First Clinical Medical College, Anhui Medical University, Hefei 230032, China; 6.Biopharmaceutical Research Institute, Anhui Medical University, Hefei 230032, China;7,School of Basic Medical Sciences, Anhui Medical University, Hefei 20032, China

Received:2022-03-04 Revised:2022-04-15 Online:2022-10-06 Published:2022-10-06
Contact: WU Xue-yan;SHEN Yu-xian E-mail:wuxueyan@ahmu.edu.cn
Supported by:
The Doctoral Research Funding Project at Anhui Medical University;The Anhui Natural Science Foundation;The National Key R&D Program of China

Abstract

Abstract:

Objective To observe the distribution of mesencephalic astrocyte derived neurotrophic factor (MANF) within the brain in human, mice and rats and the comparison across the species. Methods An immunohistochemical method was applied to investigate the expression of MANF and to compare the differences among species in the brain of human specimens (n=5), mice (n=6), and rats (n=6). Results The expression of MANF varied in different brain regions in human, mice and rats. In human, in the cortex, the expression of MANF was the highest among all brain regions. In the subcortical areas or the nucleus, brainstem and cerebellum expression level of MANF were relatively lower. The distribution of MANF in mouse and rat brain were slightly different from that in human brain, but generally consistent. Conclusion The distribution pattern of MANF is similar across the species, however, within a species, MANF expression levels varies in different brain regions.

Key words: Mesencephalic astrocyte derived neurotrophic factor, Brain distribution, Immunohistochemistry, Human, Rat, Mouse

CLC Number:

Ｒ322. 81

TANG Xiao-lu DENG Cong-cong WANG Pei CHEN Ming-hui TIAN Kai SU Yan-yan MA Hui WU Xue-yan SHEN Yu-xian. Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain[J]. Acta Anatomica Sinica, 2022, 53(5): 551-556.

References

［1］ Petrova P, Raibekas A, Pevsner J, et al. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons ［J］. J Mol Neurosci, 2003, 20(2): 173-188.

［2］ Lindholm P, Voutilainen MH, Lauren J, et al. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo ［J］. Nature, 2007, 448(7149): 73-77.

［3］ Voutilainen MH, Back S, Porsti E, et al. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson’s disease ［J］. J Neurosci, 2009, 29(30): 9651-9659.

［4］ Gao FJ, Wu JH, Li TT, et al. Identification of mesencephalic astrocyte-derived neurotrophic factor as a novel neuroprotective factor for retinal ganglion cells ［J］. Front Mol Neurosci, 2017, 10: 76.

［5］ Hartley CL, Edwards S, Mullan L, et al. Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases ［J］. Hum Mol Genet, 2013, 22(25): 5262-5275.

［6］ Apostolou A, Shen Y, Liang Y, et al. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death ［J］. Exp Cell Res, 2008, 314(13): 2454-2467.

［7］ Liu J, Zhou C, Tao X, et al. ER stress-inducible protein MANF selectively expresses in human spleen ［J］. Hum Immunol, 2015, 76(11): 823-830.

［8］ Arrieta A, Blackwood EA, Stauffer WT, et al. Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart ［J］. J Biol Chem, 2020, 295(22): 7566-7583.

［9］ Danilova T, Belevich I, Li H, et al. MANF is required for the postnatal expansion and maintenance of pancreatic beta-cell mass in mice ［J］. Diabetes, 2019, 68(1): 66-80.

［10］ Liu XC, Qi XH, Fang H, et al. Increased MANF expression in the inferior temporal gyrus in patients with Alzheimer disease ［J］. Front Aging Neurosci, 2021, 13: 639318.

［11］ Fu J, Malale K, Luo X, et al. The relationship of mesencephalic astrocyte-derived neurotrophic factor with hyperlipidemia in patients with or without type 2 diabetes mellitus ［J］. Hormones (Athens), 2021, 20(3): 537-543.

［12］Wang C, Peng JJ, Miao H, et al. Decreased plasma MANF levels are associated with type 2 diabetes ［J］. Biomed Environ Sci, 2021, 34(3): 236-240.

［13］Galli E, Planken A, Kadastik-Eerme L, et al. Increased serum levels of mesencephalic astrocyte-derived neurotrophic factor in subjects with Parkinson’s disease ［J］. Front Neurosci, 2019, 13: 929.

［14］Kovaleva V, Saarma M. Endoplasmic reticulum stress regulators: new drug targets for Parkinson’s disease ［J］. J Parkinson Dis, 2021, 11(s2): S219-S228.

［15］Xiang ChCh, Han F, Shi YX. Regulation of unfolded protein response by activated transcription factor 6 pathway and related regulatory factors in endoplasmic reticulum stress ［J］. Acta Anatomica Sinica, 2015, 46(6): 857-861. (in Chinese)

向春晨, 韩芳, 石玉秀. 内质网应激中活化转录因子6通路及相关调控因子对未折叠蛋白反应的调控［J］. 解剖学报, 2015, 46(6): 857-861.

［16］Gao FJ, Zhang SH, Li TT, et al. Expression and distribution of mesencephalic astrocyte-derived neurotrophic factor in the retina and optic nerve ［J］. Front Hum Neurosci, 2017, 10: 686.

［17］Liu J, Wu Z, Han D, et al. Mesencephalic astrocyte-derived neurotrophic factor inhibits liver cancer through small ubiquitin-related modifier (SUMO)ylation-related suppression of NF-kappaB/Snail signaling pathway and epithelial-mesenchymal transition ［J］. Hepatology, 2020, 71(4): 1262-1278.

[1]	YANG Meng-yi NIU Shi-bo ZHANG Jing DANG Jie MA Zhan-bing LU Hong HUO Zheng-hao. Association between index finger and ring finger length ratios and polymorphism of homeobox A11 gene locus among Ningxia college students [J]. Acta Anatomica Sinica, 2024, 55(1): 62-66.
[2]	HONG Xiao-min LI San-qiang CUI Qin-yi ZHENG Run-yue YANG Meng-li LUO Ren-li LI Qian-hui. Nuclear factor-κB signaling pathway and gender differences in alcoholic liver fibrosis [J]. Acta Anatomica Sinica, 2024, 55(1): 55-61.
[3]	XIE Hui-lan FANG Fang LIN Yi. Mechanism of Chir99021 regulating Wnt/β-catenin signaling pathway inhibiting osteogenic differentiation of rat dental pulp stem cells [J]. Acta Anatomica Sinica, 2024, 55(1): 67-72.
[4]	WEI Xi-xi LI Chao-hong ZHAO Chen-lu TANG Jia-ping LIU Yu-zhen. Characterization of group Ⅰ metabotropic glutamate receptors in rat superior cervical ganglion and their changes following chronic intermittent hypoxia [J]. Acta Anatomica Sinica, 2024, 55(1): 3-9.
[5]	LIU Xiao-li XU Lin WU Ai-xue WEN Cai-yun LI Ru-hua WU An-ting CHEN Dai-qian CHEN Cheng-chun. Analysis of cerebral gray matter structure in multiple sclerosis and neuromyelitis optica [J]. Acta Anatomica Sinica, 2024, 55(1): 17-24.
[6]	YUAN Lei YANG Zhi-wei YANG Hui LIU Zheng-hai HE Jie WAN Wei. Panax notoginseng saponin relieving the inflammatory pain caused by complete Freund’s adjuvant by inhibiting the activation of astrocytes in mice [J]. Acta Anatomica Sinica, 2024, 55(1): 25-31.
[7]	MA Ting-ting CHEN Jian-hong LIU Ai-cui LI Hai-ning. Role of inhibiting lncRNA TUG1 to down-regulate nucleotide binding oligomerization domain like receptor protein 1 inflammasome in delaying the progression of Alzheimer’s disease [J]. Acta Anatomica Sinica, 2024, 55(1): 32-42.
[8]	ZOU Cheng-gong FENG Hao CHEN Bing TANG Hui SHAO Chuan SUN Mou YANG Rong HE Jia-quan . Research on the dynamic changes of neurological dysfunction and cognitive function impairment in traumatic brain injury [J]. Acta Anatomica Sinica, 2024, 55(1): 43-48.
[9]	BAI He TENG Ye FENG Lei MENG Hai-wei1 TANG Yu-chun LIU Shu-wei. 3D hippocampal segmentation based on spatial and frequency domain features adaptive fusion and inter-class boundary region enhancement [J]. Acta Anatomica Sinica, 2024, 55(1): 73-81.
[10]	ZHENG Li-ping LIU Xia DU Xiao-hua WU Ya-juan LIU Shan-shan . Expression and distribution of brain-derived neurotrophic factor in different cerebrum regions of yak and cattle [J]. Acta Anatomica Sinica, 2024, 55(1): 10-16.
[11]	YIN Shi-qin YANG Si-yi WANG Rui-han YOU Gui-xuan YANG Ying-qiu ZHANG Lei. Distal tibiofibular syndesmosis fibular notch typing and its clinical significance based on CT [J]. Acta Anatomica Sinica, 2024, 55(1): 82-87.
[12]	YANG Yang SHI Jun LI Kun MA Yuan ZHANG Shao-jie HOU Er-fei WANG Chao-qun CHEN Jie WANG Xing LI Zhi-jun. Finite element analysis of cervical intervertebral discs after removing different ranges of uncinate processes [J]. Acta Anatomica Sinica, 2024, 55(1): 88-97.
[13]	SUN Lei WANG Xing-yu XIE Shui-hua. Risk analysis of re-fracture after percutaneous kyphoplasty in elderly patients with osteoporotic thoracolumbar compression fractures and construction of acolumnar graph prediction model#br# [J]. Acta Anatomica Sinica, 2024, 55(1): 98-104.
[14]	SU Peng WANG Xing-yi LIANG Jing-yan XIONG Tian-qing. Optimization and identification of a low density and high purity method for primary hippocampal neuron culture from fetal rats [J]. Acta Anatomica Sinica, 2024, 55(1): 113-119.
[15]	HAO Yong-ming GUO Lei ZHOU Cheng-hui PEI Han-jun LI Li ZHAO Zhe . Establishment of a rat model of myocardial hypertrophy by a modified abdominal aortic coarctation method [J]. Acta Anatomica Sinica, 2024, 55(1): 120-124.

Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments