Role and research progress of circular RNA in Alzheimer’s disease #br#

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doi:10.16098/j.issn.0529-1356.2023.04.017

Abstract

Abstract:

The circular RNA (circRNA) is a class of endogenous expressed non-coding RNA that are formed by covalently closed cyclization through reverse splicing. In recent years, a variety of highly conserved and cell-type specific circRNA have been identified in eukaryotes. Alzheimer’s disease (AD) is a common neurodegenerative disease and the most common cause of dementia in the elderly. Recent studies had shown that circRNA was involved in the pathogenesis and development of AD, such as amyloid β-protein (Aβ) metabolic, neuroinflammation, oxidative stress, autophagy and synaptic plasticity. The role and application value of circRNA in AD pathology are reviewed to provide a theoretical basis for the application of circRNA in the treatment and diagnosis of AD.

Key words: Circular RNA, Alzheimer’s disease, Neurodegenerative disease

CLC Number:

R741

WANG Hongfang GENG Dan-dan ZHANG Run-jiao LIU Qing LI Yi-bo WANG Lei . Role and research progress of circular RNA in Alzheimer’s disease #br#

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[J]. Acta Anatomica Sinica, 2023, 54(4): 490-494.

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Role and research progress of circular RNA in Alzheimer’s disease #br#
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