AAS ›› 2014, Vol. 45 ›› Issue (3): 430-436.doi: 10.3969/j.issn.0529-1356.2014.03.025
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NIU Miao-miao ZHAN Jun* ZHANG Hong-quan
Received:
2013-11-05
Revised:
2013-12-12
Online:
2014-06-06
Published:
2014-06-06
Contact:
ZHAN Jun
E-mail:zhanjun@bjmu.edu.cn
NIU Miao-miao ZHAN Jun* ZHANG Hong-quan. Role of HOX genes in tumor genesis and development[J]. AAS, 2014, 45(3): 430-436.
[1]ShahN, Sukumar S. The Hox genes and their roles in oncogenesis[J]. Nat Rev Cancer, 2010,10(5): 361-371. [2]Grier DG, Thompson A, Kwasniewska A, et al. The pathophysiolo-gy of HOX genes and their role in cancer[J]. J Pathol, 2005,205(2): 154-171. [3]Calvo R, West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer[J]. Proc Natl Acad Sci USA,2000,97(23): 12776-12781. [4]Ohta H, Hamada J,Tada M, et al. HOXD3-overexpression increases integrin αvβ3 expression and deprives E-cadherin while it enhances cell motility in A549 cells[J]. Clin Exp Metastasis,2006, 23(7-8): 381-390. [5]Nguyen DX, Chiang AC, Zhang X, et al. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis[J]. Cell,2009,138(1): 51-62. [6]Inamura K, Togashi Y, Ninomiya H, et al. HOXB2, an adverse prognostic indicator for stage I lung adenocarcinomas, promotes invasion by transcriptional regulation of metastasis-related genes in HOP-62 non-small cell lung cancer cells[J]. Anticancer Res,2008,28(4B): 2121-2127. [7]Rauch T, Wang Z, Zhang X, et al. Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay[J]. Proc Natl Acad Sci USA,2007,104(13): 5527-5532. [8]Kim DS, Kim MJ, Lee JY, et al. Epigenetic inactivation of homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features[J]. Mol Carcinog,2009,48(12): 1109-1115. [9]Plowright L, Harrington KJ, Pandha HS, et al. HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer) [J]. Br J Cancer, 2009,100(3): 470-475. [10]Takahashi O, Hamada J, Abe M, et al. Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma[J]. Oncol Rep, 2007,17(4): 753-760. [11]Liu DB, Gu ZD, Cao XZ, et al. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas[J]. World J Gastroenterol,2005,11(10): 1562-1566. [12]Lü J, Cao XF, Ji L, et al. Association of β-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 with the prognosis of esophageal squamous cell carcinoma[J]. Med Oncol, 2012,29(1): 151-160. [13]Gu ZD, Shen LY, Wang H, et al. HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma[J]. Cancer Res,2009,69(12): 4969-4973. [14]Han Y, Tu WW, Wen YG, et al. Identification and validation that up-expression of HOXA13 is a novel independent prognostic marker of a worse outcome in gastric cancer based on immunohistochemistry[J]. Med Oncol,2013,30(2): 564. [15]Sha S, Gu Y, Xu B, et al. Decreased expression of HOXB9 is related to poor overall survival in patients with gastric carcinoma[J]. Dig Liver Dis,2013, 45(5):422-429. [16]Kanai M, Hamada J, Takada M, et al. Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas[J]. Oncol Rep,2010,23(3): 843-851. [17]Ghoshal K, Motiwala T, Claus R, et al. HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors[J]. PLoS One,2010,5(4): e10338-e10338. [18]Jung C, Kim RS, Zhang H, et al. HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation[J]. Br J Cancer,2005,92(12): 2233-2239. [19]Vider BZ, Zimber A, Chastre E, et al. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines[J]. Biochem Biophys Res Commun,2000,272(2): 513-518. [20]Wu X, Chen H, Parker B, et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition[J]. Cancer Res,2006,66(19): 9527-9534. [21]Chiba N, Comaills V, Shiotani B, et al. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses[J]. Proc Nati Acad Sci USA,2012,109(8): 2760-2765. [22]Seki H, Sakata M, Takahashi M, et al. HOXB9 Expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients[J]. Ann Surg Oncol,2012,19(6): 1831-1840. [23]Zhang X, Zhu T, Chen Y, et al. Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene[J]. J Biol Chem,2003,278(9): 7580-7590. [24]Shaoqiang C, Yue Z, Yang L, et al. Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer[J]. Clin Exp Metastasis,2013,30(2): 155-163. [25]Carrio M, Arderiu G, Myers C, et al. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model[J]. Cancer Res,2005,65(16): 7177-7185.[26]Raman V, Martensen SA, Reisman D, et al. Compromised HOXA5 function can limit p53 expression in human breast tumours[J]. Nature,2000,405(6789): 974-978. [27]Duriseti S, Winnard JP, Mironchik Y, et al. HOXA5 regulates hMLH1 expression in breast cancer cells[J]. Neoplasia,2006,8(4): 250-258. [28]Chen H, Zhang H, Lee J, et al. HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition[J]. Cancer Res,2007,67(17): 8007-8013. [29]Chen H, Chung S, Sukumar S. HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8[J]. Mol Cell Biol,2004,24(2): 924-935. [30]Sun M, Song CX, Huang H, et al. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis[J]. Proc Natl Acad Sci USA, 2013,110(24): 9920-9925. [31]Gilbert PM, Mouw JK, Unger MA, et al. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype[J]. J Clin Invest, 2010,120(5): 1535-1550. [32]Chu MC, Selam FB, Taylor HS. HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells[J]. Cancer Biol Ther,2004,3(6): 568-572. [33]Habel LA, Sakoda LC, Achacoso N, et al. HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease[J]. Breast Cancer Res,2013,15(2): R24. [34]Li B, Jin H, Yu Y, et al. HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival[J]. Int J Gynecol Cancer,2009,19(8): 1347-1352. [35]Matei DE, Nephew KP. Epigenetic therapies for chemoresensitiza-tion of epithelial ovarian cancer[J]. Gynecol Oncol,2010,116(2): 195-201. [36]Naora H, Montz FJ, Chai CY, et al. Aberrant expression of homeobox gene HOXA7 is associated with müllerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response[J]. Proc the Natl Acad Sci USA,2001,98(26): 15209-15214. [37]Miao J, Wang Z, Provencher H, et al. HOXB13 promotes ovarian cancer progression[J]. Proc Natl Acad Sci USA,2007,104(43): 17093-17098. [38]Klausen C, Leung PC, Auersperg N. Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin[J]. Mol Cancer Res,2009,7(9): 1425-1437. [39]Morgan R, Plowright L, Harrington K J, et al. Targeting HOX and PBX transcription factors in ovarian cancer[J]. BMC Cancer,2010,10: 89. [40]Jung C, Kim RS, Lee SJ, et al. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4[J]. Cancer Res,2004,64(9): 3046-3051. [41]Kim SD, Park RY, Kim YR, et al. HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression[J]. Anat Cell Biol,2010,43(4): 284-293. [42]Norris JD, Chang CY, Wittmann BM, et al. The homeodomain protein HOXB13 regulates the cellular response to androgens[J]. Mol Cell,2009,36(3): 405-416. [43]Ren G, Zhang G, Dong Z, et al. Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers[J]. Int J Biochem Cell Biol,2009,41(5): 1094-1101. [44]Kim YR, Oh KJ, Park RY, et al. Research HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling[J]. Mol Cancer, 2010, 9: 124. [45]Chen Z, Greenwood C, Isaacs WB, et al. The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial[J]. Carcinogenesis,2013,34(6): 1260-1264. [46]Jeong TO, Oh KJ, Nguyen X, et al. Evaluation of HOXB13 as a molecular marker of recurrent prostate cancer[J]. Mol Med Rep,2012,5(4): 901-904. [47]Miller GJ, Miller HL, van Bokhoven A, et al. Aberrant HOXC expression accompanies the malignant phenotype in human prostate[J]. Cancer Res,2003,63(18): 5879-5888. [48]McCabe CD, Spyropoulos DD, Martin D, et al. Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer[J]. Cancer Res,2008,68(6): 1988-1996. [49]Axlund SD, Lambert JR, Nordeen SK. HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes[J]. Mol Cancer Res,2010,8(12): 1643-1655. [50]Kron KJ, Liu L, Pethe VV, et al. DNA methylation of HOXD3 as a marker of prostate cancer progression[J]. Lab Invest,2010,90(7): 1060-1067. [51]Nguyen Kovochich A, Arensman M, Lay AR, et al. HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma[J]. Cancer,2013,119(3): 529-539. [52]Marra L, Cantile M, Scognamiglio G, et al. Deregulation of HOX B13 expression in urinary bladder cancer progression[J]. Curr Med Chem,2013,20(6): 833-839. [53]Kocak H, Ackermann S, Hero B, et al. Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma[J]. Cell Death Disease,2013,4: e586. [54]Zhai Y, Kuick R, Nan B, et al. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion[J]. Cancer Res,2007,67(21): 10163-10172. |
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