Cell apoptosis mediated by the transcription factor cAMP response element binding protein and its regulatory mechanism

doi:10.3969/j.issn.0529-1356.2012.01.026

›› 2012, Vol. 43 ›› Issue (1): 139-144.doi: 10.3969/j.issn.0529-1356.2012.01.026

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Cell apoptosis mediated by the transcription factor cAMP response element binding protein and its regulatory mechanism

Department of Anatomy and Histology and Embryology，Medical School, Ningbo University, Zhejiang Ningbo 315211, China

Received:2011-09-29 Revised:2011-10-27 Online:2012-02-06
Contact: WANG Ping

Abstract

Abstract: Cell apoptosis is a complex and precise adjustment process, which involves numerous signal proteins. cAMP response element binding protein(CREB), a transcriptional regulation factor in eucaryotic cell, regulates the cell apoptosis through changing the intracellular signal transduction by its phosphorylation, which is a pop research in recent years. In this review, recent progress in studying the regulatory effects of transcription factor CREB on cell apoptosis is briefly summarized.

Key words: cAMP response element binding protein, Signal transduction

CLC Number:

R329

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Cell apoptosis mediated by the transcription factor cAMP response element binding protein and its regulatory mechanism

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