Protective effects of gastrodin pretreatment on rat isolated myocardial/ ischemia reperfusion injury

Abstract

Abstract: Objective： To characterize the effect of Gastrodin on the ischemia/ reperfusion I/R injury in rat hearts. Methods： Male Sprague-Dawley rat(210-260g)were randomly assigned to 6 groups:control group(Con),ischemia/reperfusion group (I/R),pre group,pre+gas（10、50、100、200μmol/L）, The isolated hearts were reperfused in the Langendorff model and were subjected to either continuous perfusion for 90min or 30min for balance，global ischemia and reperfusion respectively. Use of cardiac electrophysiology index, myocardial enzymes and myocardial morphological changes (TTC staining) to observe the three levels gastrodin preconditioning on myocardial ischemia - reperfusion injury model, To evaluate different concentrations gastrodin myocardial ischemia - reperfusion injury in the presence or absence of myocardial protection. Conclusion： Gastrodin could protect myocardium against I/R injury in rats , which might be related with its effects of restoring cardiac function.

Key words: Gastrodin, Ischemia and Reperfusion, Preconditioning

Yao Li Fei Wen Hua He Yang 无Ping Ting Ting Lai LU Di sun lin-. Protective effects of gastrodin pretreatment on rat isolated myocardial/ ischemia reperfusion injury[J]. , 2016, 47(1): 107-112.

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