Significance of CXCL10/ CXCR3 expression in the synovium of children with juvenile idiopathic arthritis

Abstract

Abstract:

Objective To investigate the expression of chemokine CXCL10 and its receptor CXCＲ3 in synovium of children with juvenile idiopathic arthritis ( JIA) and to explore the role of CXCL10 and CXCＲ3 in the pathogenesis of JIA． Methods Immunohistochemical method was used to detect CXCL10 / CXCＲ3 expression in the synovium of 12 cases of children with JIA and 4 cases of non JIA children． Semi quantitative ＲT-PCＲ was used to detect CXCＲ3 mＲNA expression in children with JIA and control．Ｒesults There were significant differences in CXCL10 / CXCＲ3 expression between children with JIA and control group ( P ＜ 0. 05) ． CXCＲ3 mＲNA expression in children with JIA ( CXCＲ3 ∶ GAPDH 2. 26 ± 1. 55) was significantly higher than that in the control group ( 0. 66 ± 0. 44，P ＜ 0. 05) ． Conclusion CXCL10 and CXCＲ3 may play important roles in the pathogenesis of juvenile idiopathic arthritis ( JIA) ．

Key words: CXCL10, CXCＲ3, Juvenile idiopathic arthritis, Immunohistochemistry, Child

CLC Number:

Ｒ322. 81

GONG Xiang-cui GUAN Hui LIU Jie. Significance of CXCL10/ CXCR3 expression in the synovium of children with juvenile idiopathic arthritis[J]. Acta Anatomica Sinica, 2017, 48(5): 590-594.

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