Research progress of 0xidative stress in tissue regeneration

doi:10.16098/j.issn.0529-1356.2018.03.024

Abstract

Abstract:

Reactive oxygen species play a critical role in cell proliferation, differentiation and apoptosis, oxidative stress, as a stress response, resultsed from the imbalance between the production and removal of reactive oxygen species within body. Low concentration of reactive oxygen species is favorable for cell growth and differentiation, and could be regarded as an essential signal to induce cell proliferation. It has been shown that the damaged animal organs, such as liver, muscle, heart, nerves, limb and tail, have ability to repair and regenerate. Tissue regeneration is closely associated with human disease and treatment, and oxidative stress is involved in these processes. This paper summarizes the role of oxidative stress and its mechanism in the process of tissue regeneration, which would provide the basis for the mechanism of regeneration and the treatment of human diseases especially regenerative medicine in the future.

Key words: Oxidative stress, Reactive oxygen species, Cell proliferation, Regeneration

GUO Jian-lin1 YAN Pei-shuo XU Cun-shuan . Research progress of 0xidative stress in tissue regeneration[J]. Acta Anatomica Sinica, 2018, 49(3): 412-418.

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