Mechanism of transient receptor potential vanilloid 1 in nasal mucosa of allergic rhinitis

doi:10.16098/j.issn.0529-1356.2018.06.027

Abstract

Abstract:

Transient receptor potential vanilloid 1(TRPV1) pathway is a non selective cation pathway, which can be activated by various stimulators such as capsaicin and high temperature, and participate in many physiological and pathological processes. As is confirmed by the latest research that the TRPV1 pathway is a core factor of mechanism of nerve immune regulation network, which plays an important role in nasal mucosa in allergic rhinitis. This article is a brief review about the research progress of TRPV1 regulating and controling neuropeptides by neural immunoregulation network which could influence the symptoms of nasal mucosa. It is expected to provide theoretical basis for clinical treatment of allergic rhinitis.

Key words: Transient receptor potential vanilloid 1, Allergic rhinitis, Nasal mucosa, Neuro-immune regulation network, Nasal symptom

LIU Li-li LIU Jian-hua JIAO Lu-lu LIU Si-ming GONG Zheng ZHANG Lin-lin BIAN Fang-zi ZHANG Lin-jing YAN Zhan-feng LIU Qiao-ping. Mechanism of transient receptor potential vanilloid 1 in nasal mucosa of allergic rhinitis[J]. Acta Anatomica Sinica, 2018, 49(6): 852-857.

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