Suppressing and activating effects of Nogo-B receptors in the pathogenesis of malignant solid tumors

doi:10.16098/j.issn.0529-1356.2021.03.025

Abstract

Abstract:

Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues. Studies have shown that Nogo-B binds to three different receptors: Nogo receptor-1 (NgR1), Nogo-B specific receptor(NgBR) and paired immunoglobulin like receptor B(PirB). These receptors play a dual role of suppression and promotion in angiogenesis, proliferation and apoptosis, invasion and migration, which are important events in tumor development and progression, through various post-receptor signaling pathways, including RhoA/Rho-associated coiled-coil contaning protein kinase(RhoA/ROCK), phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt), adenosine 5-monophosphate-activated protein kinase α/liver X receptor α(AMPAα/LXRα), extracellular signal-regulated kinase(ERK), epithelial-mesenchymal transition(EMT), unfolded protein response(UPR) and so on. An in-depth understanding of the mechanisms by which Nogo-B receptors are involved in tumor pathogene is will provide new insights into the development of drugs. Here, we will summarize the up-to-date researches on the basic structure and expression of Nogo-B/Nogo-B receptors and the suppressing/activating effects of post-receptor signaling pathways in the pathogenesis of malignant solid tumors.

Key words: Nogo-B, Receptor, Tumor, Signaling pathway

CLC Number:

R730.2

SU Hao REN Jie QIN Li-hua. Suppressing and activating effects of Nogo-B receptors in the pathogenesis of malignant solid tumors[J]. Acta Anatomica Sinica, 2021, 52(3): 489-494.

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