Distribution of Nogo in the heart and its role in cardiovascular disease

doi:10.16098/j.issn.0529-1356.2021.03.026

Abstract

Abstract:

As a member of the reticulin family, Nogo is mainly involved in processes such as tissue regeneration, apoptosis and tumor growth after tissue injury. Cardiovascular disease is one of the main diseases that threaten human health at present. In recent years, research on Nogo in the cardiovascular system has become increasingly extensive. Changes in the expression of Nogo during myocardial fibrosis, myocardial cell apoptosis and vascular remodeling suggest that it may play a certain role. This article reviews the distribution of Nogo in the heart and its role in cardiovascular disease, in order to reveal its possible role and mechanism in cardiovascular diseases.

Key words: Nogo, Myocardial infarction, Heart failure, Myocardial apoptosis, Myocardial fibrosis, Coronary vascular regulation

CLC Number:

ZHANG Su-xin SUN Yan-rong WANG Wen-juan SUN Hao-zhe HU Yao-wen QIN Lin-hua. Distribution of Nogo in the heart and its role in cardiovascular disease[J]. Acta Anatomica Sinica, 2021, 52(3): 495-498.

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