Molecular mechanism underlying vascular development in the brain

doi:10.16098/j.issn.0529-1356.2022.05.022

Abstract

Abstract:

As the pipelines of nutrient and oxygen in the brain, cerebral vessels play an important role in the development and normal function of the brain. The development of the cerebrovascular system is divided into two processes, primitive vasculogenesis and angiogenesis. In this review, we summarize the roles, regulation mechanisms, as well as the interactions of the essential signaling molecules, such as the family members of vascular endothelial growth factor (VEGF), neuropillin, Wnt, Notch, Hedgehog, in the vessel development, aiming to provide a reference for the basic and clinical investigation and the prevention and treatment of vascular diseases.

Key words: Cerebral angiogenesis, Angiogenesis, Vascular endothelial growth factor, Wnt signaling pathway, Notch signaling pathway

CLC Number:

R321
R34

ZHANG Si-qi KANG Chen-xi ZHANG Pei-yan LUO Hai-xia LI Fei SHI Juan LI Yun-qing . Molecular mechanism underlying vascular development in the brain[J]. Acta Anatomica Sinica, 2022, 53(5): 680-686.

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