Blinding eye diseases caused by retinal degeneration have a detrimental effect on human health. Mammalian retina exhibits very limited capacity for self-repair after degenerative disease or injury. In contrast, zebrafish retina possesses a robust regenerative response that regenerates all types of retinal neurons and restores vision. Retina regeneration in zebrafish depends on a type of glia cells called Müller glia. Following retinal injury, zebrafish Müller glia undergo a reprogramming process and proliferate into multipotent progenitor cells that further differentiate into newborn retinal neurons. In recent years, significant progress has been made in the field of Müller glia-based retina regeneration. Here we summarize the mechanisms governing zebrafish retina regeneration and the recent advances in mammalian Müller glia reprogramming.