Prenatal nicotine exposure induces adult offspring high response to central angiotensin II

doi:10.3969/j.issn.0529-1356.2013.02.003

Abstract

Abstract:

Objective To investigate the effect of prenatal nicotine exposure to the adult offspring response to central angiotensin. Methods The mean arterial pressure(MAP) and blood gas analysis after intracerebroventricular (ICV)injection of angiotensin II(AngII), losartan(Los), PD123319（PD）to nicotine offspring （nicotine, n =7）and control offspring（control, n =7） were tested. The angiotensin Ⅱ receptor 1 (AT1aR), AT1bR and AT2R mRNA, c-Fos protein, and AT1R, AT2R protein expression of anterior hypothalamic area(AHA) were detected. Results There was no difference between the control and nicotine groups, but after ICV AngII, the MAP was significantly higher in nicotine group than in the control group ［（120.36±6.23）mmHg vs （109.87±6.86）mmHg，P <0.05］. ICV Los in advance blocked the effect whereas ICV PD did not. The c-Fos expression was stronger in the nicotine group than that in the control group（25.8±2.91 vs 6.42±1.52, P< 0.05）. The AT1aR mRNA（1.23±0.05 vs 1.00，P < 0.05）and AT1R protein（0.581±0.06 vs 0.353±0.05，P <0.05）expression were higher in the nicotine group than that in the control group. Conclusion Prenatal nicotine exposure induces higher expression of AT1aR mRNA and AT1R protein, which may result in high response to central angiotensin II of adult offspring.

Key words: Pregnancy , Nicotine , Anterior hypothalamic area , Hyperthension, Cerebral cannula , Immunohistochemistry , Rat

YU Feng ZHANG Jian-guo GAO Xi-ren DONG Wei-jia ZHANG Zhi-zhi ZHANG Bo XIA Zhi-heng ZHANG Yu-juan * . Prenatal nicotine exposure induces adult offspring high response to central angiotensin II[J]. AAS, 2013, 44(2 ): 157-162.

References

［1］ Lim R, Sobey CG. Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring［J］. Br J Pharmacol, 2011,164(5):1397-1399.

［2］ Slotkin TA. Fetal nicotine or cocaine exposure: which one is worse［J］? J harmacol Exp Ther, 1998,285（3）: 931-945.

［3］ Dichson SL, Hrabovszky E, and Hansson C, et al. Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents ［J］. Neuroscience， 2010,171(4):1180-1186.

［4］ Bruin JE, Gerstein HC， Holloway AC. Longterm consequences of fetal and neonatal nicotine exposure: a critical review［J］. Toxicol Sci

2010,116(2):364-374.

［5］ Winzer-Serhan UH. Long-term consequences of maternal smoking and developmental chronic nicotine exposure［J］. Front Biosci， 2008, 13:636-649.

［6］ Vargas F, Rodríguez-Gómez I, Vargas-Tendero P, et al. The renin-angiotensin system in thyroid disorders and its role in cardiovascular and renal

manifestations［J］. J Endocrinol， 2012,213(1):25-36. 

［7］ Xiao D, Xu Z, Huang X,et al. Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin Ⅱ in adult offspring［J］. Hypertension, 2008, 51（4）:1239-1247.

［8］ Kubo T, Hagiwara Y. Enhanced central hypertonic saline-induced activation of angiotensin II-sensitive neurons in the anterior hypothalamic area of spontaneously hypertensive and Dahl S rats［J］. Brain Res

Bull,2006,68(5):335-340.

[9] Kubo T, Katsumata Y, Fukumori R, et al. Central nicotinic receptor blockade inhibits emotionally conditioned pressor responses in rats［J］. Experientia, 1996, 52 (4): 348-352.

[10]Ding Y, Lv J, Mao C,et al. High-salt diet during pregnancy and

angiotensin-related cardiac changes［J］. J Hypertens, 2010 ,28(6):1290-1297.

［1］ Guan J, Mao C, Xu F, et al.Low doses of nicotine induced fetal cardiovascular responses, hypoxia, and brain cellular activation in ovine fetuses［J］. Neurotoxicology, 2009,30(2):290-297.

［2］ Kubo T, Hagiwara Y. Enhanced central hypertonic saline-induced activation of angiotensin II-sensitive neurons in the anterior hypothalamic area of spontaneously hypertensive and Dahl S rats ［J］. Brain Res Bull, 2006,68(5):335-340. 

［3］ Feichao X, Caiping M, Lijun S, et al. Development of fetal brain renin-angiotensin system and hypertension programmed in fetal origins［J］. Prog Neurobiol, 2009 ,87(4):252-23. 

［4］ Guan J, Mao C,Feng X,et al. Fetal development of regulatory mechanisms for body fluid homeostasis［J］. Braz J Med Biol Res, 2008,41(6):446-454.

［5］ Nakadate K, Imamura K , Watanabe Y. Effects of monocular deprivation on the spatial pattern of visually induced expression of c-Fos protein［J］. Neuroscience,2012,27(202):17-28. 

［6］ Horiuchi M, Iwanami J, Mogi M. Regulation of angiotensin II receptors beyond the classical pathway ［J］. Clin Sci, 2012, 123 (4): 193-203.

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