AAS ›› 2014, Vol. 45 ›› Issue (3): 430-436.doi: 10.3969/j.issn.0529-1356.2014.03.025

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Role of HOX genes in tumor genesis and development

NIU Miao-miao  ZHAN Jun*  ZHANG Hong-quan   

  1. Department of Histology and Embryology, School of Basic Medicine, Peking University,Beijing 100191, China
  • Received:2013-11-05 Revised:2013-12-12 Online:2014-06-06 Published:2014-06-06
  • Contact: ZHAN Jun E-mail:zhanjun@bjmu.edu.cn

Abstract:

HOX gene belongs to a highly conserved subgroup of the homeobox superfamily. The HOX genes constitute a family of transcription factors that play key roles in embryonic development, regulating numerous processes, such us cellular growth, differentiation, apoptosis, motility and angiogenesis. The present review shows that there is a close relationship between aberrant expression of HOX genes and malignancy. This article summarizes briofly the advances in the research on HOX genes and their roles in tumor genesis.

Key words: HOX gene, Transcription factor, Tumor, Biological regulation, Immunohistochemistry