Abstract: Objective To study three-dimensional anatomy of adult coronary artery and its variations with spiral CT，and to research possible relationships of three variations to coronary artery disease(CAD). Methods Applying multislice spiral computized tomography(MSCT) of Toshiba Aquilion，by means of the software Vitrea 2 at a workstation to 3D reconstructions of the arteries，we carefully observed and measured adult coronary arterial branches，location，figures and its variation，and then analyzed some relationships of them with the occurrence of CAD. Results There were 1057 cases of coronary arteries checked with MSCT angiography，and among them 793 cases of right dominant，126 of left dominant and 138 of other types(including balancing type). This technique could illustrate the most originations and courses of coronary arteries but coronary arterial fistula. The data indicated that the left coronary dominant type has less occurrence of CAD，whereas a larger angles of emergence of the left coronary artery，a very short main stem of the artery and a variation of the arterial debouchement were factors that have a marked positive correlativity with CAD. Conclusions MSCT could stereoscopically illustrate coronary arteries but it can not yet replace its true anatomy. Intere

Key words: Coronary artery, Variation, Coronary artery disease, Cross-sectional imaging, Multi-slice spiral computed tomography, Human