骨血管形成机制及功能的研究进展

doi:10.16098/j.issn.0529-1356.2019.05.027

解剖学报 ›› 2019, Vol. 50 ›› Issue (5): 703-706.doi: 10.16098/j.issn.0529-1356.2019.05.027

• 综述 • 上一篇

骨血管形成机制及功能的研究进展

李旭陈依民王鼎予沈重成张卫光*

北京大学基础医学院人体解剖学与组织学胚胎学系，北京 100191

收稿日期:2018-07-23 修回日期:2018-07-23 出版日期:2019-10-06 发布日期:2019-12-10
通讯作者: 张卫光 E-mail:zhangwg@bjmu.edu.cn
基金资助:
北京大学医信种子基金

Advances of mechanism and function of bone vascularization

LI Xu CHEN Yi-min WANG Ding-yu SHEN Zhong-cheng ZHANG Wei-guang*

Department of Anatomy and Embryology，School of Basic Medical Sciences， Peking University， Beijing 100191， China

Received:2018-07-23 Revised:2018-07-23 Online:2019-10-06 Published:2019-12-10
Contact: ZHANG Wei-guang E-mail:zhangwg@bjmu.edu.cn

摘要/Abstract

摘要：

骨血管系统不仅为高代谢的骨细胞提供氧气与营养物质，也参与骨形成与骨再生过程。骨组织毛细血管可分为两种亚型，它们具有不同的形态和生理特点。内皮细胞与骨细胞通过多种信号通路沟通，血管形成与骨形成也具有协同作用。对骨血管结构及血管形成信号通路的探索有助于骨折愈合临床治疗的发展。

关键词: 骨, 血管形成, 骨折愈合

Abstract:

The vascular system in bone not only provides oxygen and nutrients to highly anabolic skeletal cells, but also participates in the process of bone formation and bone regeneration. Based on morphological and physiological characteristics, two subtypes of bone capillaries can be distinguished. Endothelial cells and osteoprogenitor cells influence each other by secreting specific growth factors, which have an important role in the coupling of angiogenesis and osteogenesis. A greater understanding of the architecture of the bone vasculature and the angiogenic response may contribute to enhanced bone regeneration.

Key words: Bone, Angiogenesis, Fracture healing

李旭陈依民王鼎予沈重成张卫光. 骨血管形成机制及功能的研究进展[J]. 解剖学报, 2019, 50(5): 703-706.

LI Xu CHEN Yi-min WANG Ding-yu SHEN Zhong-cheng ZHANG Wei-guang. Advances of mechanism and function of bone vascularization[J]. Acta Anatomica Sinica, 2019, 50(5): 703-706.

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骨血管形成机制及功能的研究进展

Advances of mechanism and function of bone vascularization

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