强迫症患者大脑灰质体积变化——基于体素的形态学分析

doi:10.16098/j.issn.0529-1356.2021.05.004

解剖学报 ›› 2021, Vol. 52 ›› Issue (5): 692-697.doi: 10.16098/j.issn.0529-1356.2021.05.004

强迫症患者大脑灰质体积变化——基于体素的形态学分析

李若川¹ 唐洁² 杨勇锋³ 樊令仲² 张海东^4*

1. 山东第一医科大学（山东省医学科学院）基础医学院2018级，济南 250000; 2.中国科学院自动化研究所，北京 100190; 3.新乡医学院第二附属医院河南省生物精神病重点实验室，河南新乡 453002; 4.山东第一医科大学（山东省医学科学院）临床医学院，济南 250000

收稿日期:2020-11-23 修回日期:2021-02-05 出版日期:2021-10-06 发布日期:2021-10-06
通讯作者: 张海东 E-mail:tsmchdzhang@163.com
基金资助:
山东省大学生创新创业计划项目;山东第一医科大学大学生科研计划项目

Gray matter abnormalities in obsessive-compulsive disorder by voxel-based morphometry research#br#

LI Ruo-chuan¹ TANG Jie² YANG Yong-feng³ FAN Ling-zhong² ZHANG Hai-dong^4*#br#

1.School of Basic Medicine, Grade 2018, Shandong First Medical University(Shandong Academy of Medical Sciences), Ji’nan 250000, China; 2.Institute of Automation, Chinese Academuy of Sciences, Beijing 100190, China; 3.He’nan Key Laboratory of Biological Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, He’nan Xinxiang 453002, China; 4.School of Clinical Medicine, Shandong First Medical University(Shandong Academy of Medical Sciences), Ji’nan 250000, China

Received:2020-11-23 Revised:2021-02-05 Online:2021-10-06 Published:2021-10-06
Contact: ZHANG Hai-dong E-mail:tsmchdzhang@163.com

摘要/Abstract

摘要：

目的探讨强迫症（OCD）患者大脑灰质体积的变化，并分析其在发病过程中可能存在的相关机制。方法选择31例年龄17~47岁重度强迫症患者和31例正常对照被试者，获取脑结构磁共振T1图像，使用基于体素的形态学测量（VBM）方法，比较强迫症组和对照组大脑灰质体积的差异，并将患者灰质体积差异区与其临床评分进行相关分析。结果与对照组相比，OCD患者在左侧壳核、岛叶、运动前区、顶上小叶以及右侧角回处体积显著减小。左侧壳核和岛叶的体积与患者贝克焦虑量表（BAI）评分成显著负相关。结论左侧壳核、岛叶、运动前区、顶上小叶以及右侧角回的灰质体积变化影响了该脑区功能，从而导致了OCD患者的部分症状。其中左侧壳核以及岛叶的损伤与患者焦虑情绪的异常密切相关。

关键词: 强迫症, 灰质体积, 基于体素的形态学测量, 磁共振成像, 人

Abstract:

Objective To investigate the abnormalities of gray matter volume in obsessive-compulsive disorder(OCD) patients relative to controls using the method of voxel-based morphometry(VBM), and to analyze the extent of change relative to clinical symptom. Methods Using VBM to compare the MRI images of 31 adult OCD patients with 31 healthy controls. Correlation analyses were conducted between the structural abnormalities of gray matter volume in each brain area among patients relative to their clinical scores. Results Compared with the healthy controls, the OCD patients showed reductions of gray matter volume in left putamen, insula, premotor area, superior parietal and right angular gyrus (P<0.01,Alphasim corrected). The gray matter volumes of left putamen and insular in the OCD patients showed a negative correlation with the Beck anxiety inventory(BAI) scores. Conclusion The changes in gray matter volumes of left putamen, insula, premotor area, superior parietal lobule and right angular gyrus may be related to the pathogenesis of OCD. The declines of left putamen and insula are related to the abnormal anxiety in the OCD patients.

Key words: Obsessive-compulsive disorder, Gray matter volume, Voxel-based morphometry, Magnetic resonance imaging, Human

中图分类号:

R395.1

李若川唐洁杨勇锋樊令仲张海东. 强迫症患者大脑灰质体积变化——基于体素的形态学分析[J]. 解剖学报, 2021, 52(5): 692-697.

LI Ruo-chuan TANG Jie YANG Yong-feng FAN Ling-zhong ZHANG Hai-dong. Gray matter abnormalities in obsessive-compulsive disorder by voxel-based morphometry research#br#[J]. Acta Anatomica Sinica, 2021, 52(5): 692-697.

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强迫症患者大脑灰质体积变化——基于体素的形态学分析

Gray matter abnormalities in obsessive-compulsive disorder by voxel-based morphometry research#br#

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