心肌梗死动物模型的建立和应用

doi:10.16098/j.issn.0529-1356.2024.02.018

摘要/Abstract

摘要：

心肌梗死是严重的心血管疾病之一，患者最终死于心力衰竭或心律失常。近年来，心肌梗死治疗的研究取得了很大进展，特别是临床前实验研究。心肌梗死的实验研究常依赖于动物模型，故心肌梗死模型的成功建立对于探索修复梗死心肌的新技术和新措施具有重要的应用价值。本文中我们对心肌梗死模型建立的技术和应用策略作了综述。

关键词: 冠状动脉, 心肌梗死, 心肌再生, 血管新生, 动物模型

Abstract:

Myocardial infarction is one of the severe cardiovascular diseases. The patients with myocardial infarction die of heart failure or arrhythmia. In recent years, the studies in myocardial infarction therapies have advanced greatly, especially the preclinical experimental studies. The experimental studies of myocardial infarction often rely on animal models. Therefore, successful establishment of the myocardial infarction models has important application value in exploring the new techniques and measures for repairing the infarcted myocardium. In this paper, the techniques in establishment of the myocardial infarction models and strategies of their application are summarized.

Key words: Coronary artery, Myocardial infarction, Myocardial regeneration, Angiogenesis, Animal model

中图分类号:

R541.1
R322

王海杰谭玉珍. 心肌梗死动物模型的建立和应用[J]. 解剖学报, 2024, 55(2): 247-252.

WANG Hai-jie TAN Yu-zhen. Establishment and application of animal models of myocardial infarction[J]. Acta Anatomica Sinica, 2024, 55(2): 247-252.

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