关键词: 人参皂甙Rh2, 移植瘤, 淋巴管生成, 血管内皮生长因子C, 免疫组织化学, 小鼠

Abstract: Objective The effects of ginsenoside Rh2 were observed on the growth of transplanted tumors, In addition, We studied the mechanisms of expression of vascular endothelial growth factor-C(VEGF-C) and the density of lymphatic vessels in mice, and to study its mechanism. \ Methods\ Models were established by inoculating S180 cells under skin of 55 mice, and the ginsenoside Rh2 was administrated only in medication group after tumors were founded. All mice were observed for their tumors growth. Using immunohistochemical method, we investigated the expression of VEGF-C and the density of lymphatic vessels in both groups at 2 and 3 weeks separately.\ Results\ In the control group, the tumors grew faster than in the 3 weeks medication group. At the 2 weeks of administration, we found the density of VEGF-C and lymphtic vessels in tumors had no difference between medication group and control group. However, after 3 weeks they were lower in the medication group as compared to the control group (P<0.05).\ Conclusion\ Ginsenoside Rh2 administration blocked the growth of tumors and decreased the density of lymphatic vessels in obviously. The mechanism could be that ginsenoside Rh2 can weakened the expression of VEGF-C, and then interfered with the lymphangiogenesis in the transplanttumors.

Key words: Ginsenoside Rh2, Transplanted tumor, Lymphangiogenesis, VEGF-C, Immunohistochemistry, Mouse