解剖学报

›› 2011, Vol. 42 ›› Issue (1): 141-143.doi: 10.3969/j.issn.0529-1356.2011.01.027

• 技术方法 • 上一篇    

利用Micro-PET显像技术分析阿尔茨海默病小鼠模型的脑糖代谢

高凯;袁树民;董伟;张连峰*   

  1. 中国医学科学院北京协和医学院实验动物研究所，卫生部人类疾病比较医学重点实验室，北京 100021
  • 收稿日期:2010-07-23 修回日期:2010-09-08 出版日期:2011-01-06
  • 通讯作者: 张连峰

Analysis of cerebral glucose metabolism in mouse of Alzheimer’s disease model by Micro-PET

  1. Key Laboratory of Human Disease Comparative Medicine, Ministry of Heath, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
  • Received:2010-07-23 Revised:2010-09-08 Online:2011-01-06
  • Contact: ZHANG Lian-feng

关键词: 阿尔茨海默病, 葡萄糖摄取, 正电子发射断层扫描, 小动物PET, 小鼠

Abstract: Objective To evaluate the cerebral glucose metabolism of Alzheimer’s disease(AD) model mouse by SUP>18/SUP>F-FDG and MicroPET，and develop an imaging technique to evaluate AD drugs therapeutic effect on animal models. Methods The 9 mice of control group, APPSUP>swe/SUP>/PSΔE9 doubletransgenic group and aricept treatment group［2 mg/(kgI>&#/I>8226;d)］ were injected SUP>18/SUP>F-FDG by peritoneal cavity and scanned by Micro-PET. The glucose uptake value of cerebrum，frontal cortex and temporal cortex region of interest(ROI) were analysed by IRW software. Results The images of SUP>18/SUP>F-FDG and Micro-PET could be used to detect the cerebral glucose metabolism of AD mouse model. We found that the cerebral glucose metabolism was decreased in the APPSUP>swe/SUP>/PSΔE9 doubletransgenic mice, which was consistent with phenotype of the human AD. Aricept treatment improved the cerebral glucose metabolism of AD disease model mice. Conclusion The imaging analysis using SUP>18/SUP>F-FDG an

Key words: Alzheimer’s disease, Glucose uptake, Positron emission computerized tomography, Micro-PET, Mouse

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