›› 2011, Vol. 42 ›› Issue (3): 361-366.doi: 10.3969/j.issn.0529-1356.2011.03.014

• 论著 • 上一篇    下一篇

阿托伐他汀对哮喘大鼠过氧化物酶体增殖因子活化受体γ的作用及气道重塑的影响

刘明伟1*; 苏美仙2 ;蔡绍曦3;李岚1;何杰明1   

  1. 1.云南省昆明市延安医院呼吸二科,昆明 650051; 2.昆明医学院第二附属医院外科重症监护室,昆明 650101;3.南方医科大学附属南方医院呼吸科,广州 510515
  • 收稿日期:2010-09-27 修回日期:2011-01-10 出版日期:2011-06-06
  • 通讯作者: 刘明伟

Effect of atorvastatin on airway remodeling and peroxisome proliferators-activated receptor-gamma expression and its mechanism in asthmatic rats

  1. 1.The Second Department of Respiratory Medicine,Affiliated Yanan Hospital of Kunming Medical College,Kunming 650051,China;2.Surgical Intensive Care Unit,the Second Affiliated Hospital of Kunming Medical College, Kunming 650101,China;3.Department of Respiratory Diseases,the Affiliated Nanfang Hospital of Southern Medical University, Guangzhou 510515,China
  • Received:2010-09-27 Revised:2011-01-10 Online:2011-06-06
  • Contact: LIU Ming-wei

关键词: 阿托伐他汀, 过氧化物酶增殖体激活受体γ, 支气管重塑, 免疫组织化学, 大鼠

Abstract: Objective To investigate the effect of hydroxyl-methylglutaryl-CoA(HMG-CoA) reductase inhibitor,atorvastatin,on airway remodeling in asthmatic rats. Methods The male Sprague-Dawly rats were randomly divided into 4 groups with 20 rats in each group:the control group,the model group,the dexamethasone treated group and the atorvastatin treatment group.The asthmatic rat model was established by intraperitoneal injection and repeated inhalation of 10g/L ovalbumin.The changes of collagen typeⅢ,peroxisome proliferators-activated receptor-gamma(PPAR-γ),the nurmber of nuclear factor-κβ-positive cells,inflammatory cells in the airway wall,were detected by immunohistochemical and pathological methods;the internal perimeter of bronchi(Pi),the area of bronchial smooth muscle(WAm) and bronchus wall were measured by the computerized image analysis system. Results 1. The numbers of eosinophils, lymphocytes, nuclear factor-κβ-positive cells,the contents of collagen typeⅢwere lower and the expression of PPAR-γ was higher in atorvastatin group than that of the model group,the difference being significant(all EM>P/EM><0.05); compared with dexamethasone no statistically significant(EM>P/EM>>0.05); The WAm/Pi, bronchu smooth muscle area/Pi, N/Pi in atorvastatin group were lower than that of the model group,the difference was significant(all EM>P/EM><0.05).The negative correlation was found between expression of PPAR-γ and the nurmber of nuclear factor-κβ-positive cell (rs=-0.530,EM>P/EM><0.05).Conclusion Atorvastatin can promo

Key words: Atorvastatin, Peroxisome proliferators-activated receptor-γ, Airway remodeling, Immunohistochemistry, Rat

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