解剖学报 ›› 2013, Vol. 44 ›› Issue (4 ): 580-584.doi: 10.3969/j.issn.0529-1356.2013.04.026

• 综述 • 上一篇    

神经元树突非典型运输途径的微结构和功能的研究进展

强文斌 张筱敏 罗建红*   

  1. 浙江大学医学院神经科学系,  杭州 310058
  • 收稿日期:2012-07-13 修回日期:2012-09-05 出版日期:2013-08-06 发布日期:2013-09-04
  • 通讯作者: 罗建红 E-mail:luojianhong@zju.edu.cn
  • 基金资助:

    国家973计划基金资助项目

Review of the major components of neuron dendrites and their function in noncanonical transportation

QIANG Wen-bin ZHANG Xiao-min LUO Jian-hong*   

  1. Department of Neuroscience,Medical School,Zhejiang University, Hangzhou 310058, China
  • Received:2012-07-13 Revised:2012-09-05 Online:2013-08-06 Published:2013-09-04

摘要:

细胞中蛋白质的合成和运输是复杂而严格调控的过程,在结构高度特异化的神经元细胞更是如此。神经元树突中存在着不同于其他细胞的独立于胞体运输途径的非典型运输途径,其构成主要有树突mRNA、树突内质网(dER)和树突“外驻”高尔基体(Golgi outposts)。关于这
些细胞微结构的形态分布,其非典型运输的功能以及相关病理学研究近几年有重要的进展。

关键词: 非典型运输, 树突棘, 树突“外驻”高尔基体

Abstract:

Objective Proteins synthesis and transportation in cells are complex processes and have been strictly controlled, especially in neurons which possess many specialized structures. The non-canonical transportation in dendrites is different
from canonical transportation in the soma, as the former mainly consists of dendrite mRNA, dendrite endoplasmic reticulum and Golgi outposts. In recent years, many studies have been undertaken to elucidate the appearance, function and roles of organells
in pathology during non-canonical transportation.

Key words: Non-canonical transportation, Spine apparatus, Golgi outposts