钙调蛋白激酶Ⅱ的结构及其在神经系统中的作用

doi:10.16098/j.issn.0529-1356.2019.03.022

解剖学报 ›› 2019, Vol. 50 ›› Issue (3): 395-399.doi: 10.16098/j.issn.0529-1356.2019.03.022

钙调蛋白激酶Ⅱ的结构及其在神经系统中的作用

王彤彤^1,2陈治池^1,2 叶鑫^1,2 傅维达³陈梦娇³ 李俊楠³ 孙臣友^1,2*

1.温州医科大学基础医学院人体解剖学教研室，浙江温州 325035; 2.温州医科大学基础医学院神经科学研究所，浙江温州 325035; 3.温州医科大学第一临床医学院，浙江温州 325035

收稿日期:2018-07-11 修回日期:2018-08-21 出版日期:2019-06-06 发布日期:2019-06-06
通讯作者: 孙臣友 E-mail:sunchenyou1972@aliyun.com
基金资助:
国家自然科学基金;浙江省医药卫生科学研究计划

Structure of calcium/calmodulin-dependent protein kinase type Ⅱ and its role in nervous system

WANG Tong-tong ^1,2 CHEN Zhi-chi^1,2 YE Xin^1,2 FU Wei-da³ CHEN Meng-jiao³ LI Jun-nan³SUN Chen-you ^1,2*

1.Department of Anatomy，School of Basic Medical Sciences, Wenzhou Medical University, Zhejiang Wenzhou 325035， China; 2.Institution of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University，Zhejiang Wenzhou 325035，China; 3.The First Clinical Medical College，Wenzhou Medical University，Zhejiang Wenzhou 325035， China

Received:2018-07-11 Revised:2018-08-21 Online:2019-06-06 Published:2019-06-06
Contact: SUN Chen-you E-mail:sunchenyou1972@aliyun.com

摘要/Abstract

摘要：

钙离子（Ca²⁺ ）是通过局部信号获得特异性刺激的关键细胞内信使分子。Ca²⁺ 结合蛋白，如钙调蛋白（CaM）及其靶蛋白是Ca²⁺ 依赖性反应信号传导的关键靶点。钙/钙调蛋白依赖性蛋白酶Ⅱ（CaMKⅡ）是一种多聚体酶，它是哺乳动物前脑总蛋白的重要组成部分，并且是形成突触后致密部的主要成分。近年来国内外研究显示，CaMKⅡ包含α、β、γ 和 δ 4种亚型，其中α 和 β 主要在神经组织中表达，而 γ 和 δ 则在全身多种组织均有表达，它们参与特定的突触可塑性和记忆巩固过程，对神经系统的兴奋性及一些神经系统疾病的发生起重要作用。前期也有研究表明CaMKⅡδ在促进神经元存活中起重要作用。本文就CaMKⅡ的结构及其在神经系统中的作用和与相关神经系统疾病的关系作一综述。

关键词: 钙离子, 钙调蛋白, 钙调蛋白激酶Ⅱ

Abstract:

Calcium (Ca²⁺ ) has long been recognized as a crucial intracellular messenger attaining stimuli specific cellular outcomes via localized signaling. Ca²⁺ binding proteins, such as calmodulin (CaM) and its target proteins are key to Ca²⁺ -dependent signaling events. Calcium/calmodulin-dependent protein kinase type Ⅱ (CaMKⅡ) is a highly abundant polymer enzyme comprising a significant fraction of total protein in mammalian forebrain and forming a major component of the postsynaptic density. In recent years, studies have shown that CaMKⅡ contains four subtypes of α, β, γ and δ, in which CaMKⅡ α and β are mainly expressed in nerve tissues and γ and δ are expressed in the whole body. They are essential for certain synaptic plasticity and memory consolidation processes, both in the central nervous system and in the excitability of the nervous system and in some neurological diseases. CaMKⅡ may play an important role in the pathogenesis of some nervous system diseases. Previous studies have also shown tha CaMKⅡδ plays an important role in promoting neuronal survival. The structure of CaMKⅡ and its role in nervous system and its relationship with related nervous system diseases will be reviewed.

Key words: Calcium, Calmodulin, Calcium/calmodulin-dependent protein kinase type Ⅱ

王彤彤陈治池叶鑫傅维达陈梦娇李俊楠孙臣友. 钙调蛋白激酶Ⅱ的结构及其在神经系统中的作用[J]. 解剖学报, 2019, 50(3): 395-399.

WANG Tong-tong CHEN Zhi-chi YE Xin FU Wei-da CHEN Meng-jiao LI Jun-nan SUN Chen-you. Structure of calcium/calmodulin-dependent protein kinase type Ⅱ and its role in nervous system[J]. Acta Anatomica Sinica, 2019, 50(3): 395-399.

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钙调蛋白激酶Ⅱ的结构及其在神经系统中的作用

Structure of calcium/calmodulin-dependent protein kinase type Ⅱ and its role in nervous system

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