解剖学报

解剖学报 ›› 2014, Vol. 45 ›› Issue (1): 41-46.doi: 10.3969/j.issn.0529-1356.2014.01.008

• 神经生物学 • 上一篇    下一篇

单胺类神经元在成年树鼩中枢神经系统中的分布

蓝薇 丁玉强*   

  1. 同济大学医学院人体解剖学与神经生物学系，上海 200092
  • 收稿日期:2013-05-21 修回日期:2013-08-15 出版日期:2014-02-06 发布日期:2014-02-06
  • 通讯作者: 丁玉强 E-mail:dingyuqiang@gmail.com

Distribution of monoaminergic neurons in the central nervous system of adult tree shrew

LAN Wei DING Yu-qiang*   

  1. Department of Anatomy and Neurobiology, School of Medicine, Tongji University，Shanghai 200092，China
  • Received:2013-05-21 Revised:2013-08-15 Online:2014-02-06 Published:2014-02-06
  • Contact: DING Yu-qiang E-mail:dingyuqiang@gmail.com

摘要：

目的 探讨酪氨酸羟化酶（TH）和色氨酸羟化酶2（Tph2）在成年树鼩中枢神经系统（CNS）中的分布特征。方法 利用免疫组织化学技术观察TH和Tph2在成年树鼩CNS的分布特征。结果 在成年树鼩CNS中，TH阳性信号主要分布于嗅球小球层、纹状体、第3脑室周围区域、未定带、黑质、腹侧被盖区、中央管周围灰质和蓝斑；而成年树鼩CNS中的Tph2阳性信号主要分布于中脑和脑桥中缝复合结构中。结论 树鼩TH和Tph2阳性信号的分布模式与脊椎动物的总体分布模式大致相同；某些细节特征显示，树鼩在进化上更接近灵长动物。

关键词: 酪氨酸羟化酶, 色氨酸羟化酶2, 分布, 免疫组织化学, 树鼩

Abstract:

Objective To explore the distribution of tyrosine hydroxylase (TH) and tryptophan hydroxylase 2 (Tph2) in the CNS of the adult tree shrew (Tupaia belangeri chinensis). Methods TH and Tph2 expressions in the adult tree shrew were localized using immunohistochemistry. Results TH-immunoreactive signals were mainly distributed in the glomerular layer of the olfactory bulb, striatum, paraventricular hypothalamic nucleus, subtantia nigra, ventral tegmental area and locus coeruleus. Tph2- immunoreactive signals were mainly located in the midbrain and the pontine raphe complex. Conclusion The distribution pattern of TH and Tph2 in the tree shrew CNS is consistent with that of most vertebrate. Some distribution characteristics shown in the tree shrew support its close afnity to primates. The distribution pattern of TH and Tph2 in the tree shrew CNS indicates the conservation of the evolution of the dopamine and serotonin systems, and suggests that the tree shrew can be a potential animal model to study human mental diseases associated with the dopamine and serotonin systems.

Key words: Tyrosine hydroxylase, Tryptophan hydroxylase 2, Distribution, Immunohistochemistry, Tree shrew