Apelin/APJ信号在肝硬化及肝癌中的生物作用

doi:10.16098/j.issn.0529-1356.2018.01.022

摘要/Abstract

摘要：

Apelin/APJ信号在心脏、血管、脑、肺、胃肠道、肾脏和骨骼肌等多种组织中都有表达，可以参与多种细胞的信号转导过程，所以在调节人体生理和病理生理活动方面可发挥重要的调节作用。Apelin/APJ信号的作用主要包括调节心血管系统的稳态、维持水电解质的平衡、促进垂体激素释放、调节生物节律，还可以作为免疫调节因子对免疫系统进行调节。但是apelin/APJ信号在肝脏疾病中发挥什么样的作用还知之甚少。在肝脏疾病中，apelin/APJ信号可能参与到肝纤维化、肝硬化和肝癌的发生和发展，并且可抑制肝脏的再生。我们对apelin/APJ信号近年来在肝脏方面的研究做一综述。

关键词: Apelin, APJ, 信号, 肝硬化, 肝癌, 人

Abstract:

Apelin/APJ is a G-protein-coupled receptors signal, which is widespread in human and animal tissues including brain, lung, heart, vessels, gastrointestinal tract and kidney, et al. The system plays a vital role in regulating the physiological activities of the human body by participating in multitudinous cell signaling transduction process. Apelin/APJ function mainly includes the regulation of the cardiovascular system homeostasis, maintaining water and electrolyte balance, promoting pituitary hormone release and regulating biological rhythm, and regulating the immune system as an immunomodulatory factor. However, apelin/APJ function is still unknown. In liver, apelin-APJ signal may promote the development of liver fibrosis, cirrhosis and cancer and may play an inhibitory role in liver regeneration. In this review, we summarise the function of apelin/APJ system in hepatic disease.

Key words: Apelin, APJ, Signal, Liver cirrhosis, Hepatocellular carcinoma, Human

林波潘韦彤孔静吕心瑞. Apelin/APJ信号在肝硬化及肝癌中的生物作用[J]. 解剖学报, 2018, 49(1): 127-131.

LIN Bo PAN Wei-tong KONG Jing Lü Xin-rui. Function of apelin/APJ signal in liver cirrhosis and hepatocellular carcinoma[J]. Acta Anatomica Sinica, 2018, 49(1): 127-131.

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