神经烯醇化酶与中枢神经系统发育、损伤修复的研究进展

doi:10.16098/j.issn.0529-1356.2018.03.021

摘要/Abstract

摘要：

神经烯醇化酶（NSE）作为神经元发育、重塑的特异性标志物，在中枢神经系统发育和损伤修复过程中呈时空性表达分布。损伤后NSE的改变可以反映病理变化，通过调节NSE水平可以达到损伤后的修复效果，对神经系统的损伤修复有重要意义。本文中我们就NSE的分子结构、表达调控、生物学功能及其与中枢神经系统发育、损伤修复关系进行综述。

关键词: 中枢神经系统, 神经烯醇化酶, 发育, 损伤, 修复

Abstract:

As a specific marker of neuron development and reconstruction, neuron specific enolase (NSE) expresses the spatiotemporal distribution in the development and repair of central nervous system. The change of NSE after central nervous system injury can reflect the pathological changes, and can adjust the level of NSE to achieve the effect of post injury repair. It is important for the repair and damage of the nervous system. In this review, we review the molecular structure, expression regulation, biological function of NSE and its relationship with the development, injury and repair of the central nervous system.

Key words: Central nervous system, Neuron specific enolase, Development, Injury, Repair

周静莹张宋欧孟晓芳刘学红. 神经烯醇化酶与中枢神经系统发育、损伤修复的研究进展[J]. 解剖学报, 2018, 49(3): 395-399.

ZHOU Jing-ying ZHANG Song-ou MENG Xiao-fang LIU Xue-hong. Research progress of neuron specific enolase in development，injury and repair of the central nervous system[J]. Acta Anatomica Sinica, 2018, 49(3): 395-399.

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