Janus激酶-信号转导及转录激活因子信号转导通路调控神经发生

doi:10.16098/j.issn.0529-1356.2019.05.024

摘要/Abstract

摘要：

Janus激酶-信号转导及转录激活因子（JAK-STAT）信号转导通路与细胞生物学活动及许多疾病的发生、发展相关。近年来，在中枢神经系统中发现，JAK-STAT信号转导通路对于神经退行性疾病和神经损伤后神经再生具有一定的调控作用；而促进内源性神经发生作为神经再生研究的新方向，也与JAK-STAT信号转导通路的正负调控密切相关。现就JAK-STAT信号转导通路，神经发生，以及JAK-STAT信号转导通路调控神经发生的研究进展做一综述。

关键词: Janus激酶, 信号转导及转录激活因子, 神经发生

Abstract:

Janus kinase-signal transducers and activators of transcription (JAK-STAT) signal transduction pathway is related to cellular biological activities and occurrence and development of many diseases. In recent years, JAK-STAT signal transduction pathway has been found in the central nervous system to regulate neurodegenerative diseases and nerve regeneration after nerve injury；however, promoting endogenous neurogenesis as a new direction of nerve regeneration research is also closely related to the positive or negative regulation of JAK-STAT signal transduction pathway. This article reviews the research progress of JAK-STAT signal transduction pathway, neurogenesis, and JAK-STAT signal transduction pathway regulating neurogenesis.

Key words: Janus kinase, Signal transducers and activators of transcription, Neurogenesis

刘矿嫔马微杨金伟代云飞郭建辉李力燕. Janus激酶-信号转导及转录激活因子信号转导通路调控神经发生[J]. 解剖学报, 2019, 50(5): 684-689.

LIU Kuang-pin MA Wei YANG Jin-wei DAI Yun-fei GUO Jian-hui LI Li-yan.

Research progress of janus kinase - signal transducers and activators of transcription signal transduction pathway and neurogenesis

[J]. Acta Anatomica Sinica, 2019, 50(5): 684-689.

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