环状RNA及其在肝病中的作用

doi:10.16098/j.issn.0529-1356.2019.05.025

解剖学报 ›› 2019, Vol. 50 ›› Issue (5): 690-697.doi: 10.16098/j.issn.0529-1356.2019.05.025

环状RNA及其在肝病中的作用

王棋文¹ 李盼¹王嵩雲¹ 郭学强¹张春艳¹ 杨亚军² 李剑勇^2* 徐存拴^1*

1.河南师范大学生命科学学院，省部共建细胞分化调控国家重点实验室培育基地，河南新乡 453007; 2.中国农业科学院兰州畜牧与兽药研究所，农业部兽用药物创制重点实验室/甘肃省新兽药工程重点实验室，兰州 730050

收稿日期:2018-08-01 修回日期:2018-10-29 出版日期:2019-10-06 发布日期:2019-12-10
通讯作者: 李剑勇;徐存拴 E-mail:lijy1971@163.com
基金资助:
国家自然基金

Circular RNA and its role in liver diseases

WANG Qi-wen¹LI Pan¹ WANG Song-yun¹ GUO Xue-qiang¹ ZHANG Chun-yan¹ YANG Ya-jun² LI Jian-yong^2* XU Cun-shuan ^1*

1.State Key Laboratory Cultivation Base for Cell Differentiation Regulation, College of Life Science, He’nan Normal University, Xinxiang 453007, China; 2.Key Laboratory of New Animal Drug Project of Gansu Province,Key Laboratory of Veterinary Pharmaceutical Development,Ministry of Agriculture,Lanzhou Institute of Husbandry and Pharmaceutical Science of Chinese Academy of Agricultural Sciences, Lanzhou 730050,China

Received:2018-08-01 Revised:2018-10-29 Online:2019-10-06 Published:2019-12-10
Contact: LI Jian-yong;XU Cun-shuan E-mail:lijy1971@163.com

摘要/Abstract

摘要：

环状RNA（circRNA）是一种不具有5’末端帽子结构和3’末端的poly（A）尾巴的新型非编码RNA，是由非共价键形成的反向连接的闭合环状结构。circRNA由于其具有作为miRNA分子海绵及生物标志物的作用，可用于肝脏疾病的治疗和诊断，因此，circ RNA已逐渐成为当今的研究热点。我们针对circRNA以及circRNA在肝病中的研究进行了综述，以期对未来的肝脏疾病的研究和治疗提供理论基础和新思路。

关键词: 环状RNA, 生物学功能, 肝脏疾病

Abstract:

The circular RNA (circ RNA) is a novel non-coding RNA having no 5’ end cap structure and a 3’ end poly(A) tail, and is a reversely linked closed loop structure formed by non-covalent bonds. Due to its role as a sponge for miRNA molecules and biomarker, circular RNA can be used in the treatment and diagnosis of liver diseases, and it has increasingly become a research hotspot. In this paper, the research on circRNA and circRNA in liver disease is reviewed, in order to provide theoretical basis and new ideas for the research and treatment of future liver diseases.

Key words: Circular RNA, Biological function, Liver disease

王棋文李盼王嵩雲郭学强张春艳杨亚军李剑勇徐存拴 . 环状RNA及其在肝病中的作用[J]. 解剖学报, 2019, 50(5): 690-697.

WANG Qi-wen LI Pan WANG Song-yun GUO Xue-qiang ZHANG Chun-yan YANG Ya-jun LI Jian-yong XU Cun-shuan. Circular RNA and its role in liver diseases[J]. Acta Anatomica Sinica, 2019, 50(5): 690-697.

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环状RNA及其在肝病中的作用

Circular RNA and its role in liver diseases

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