解剖学报 ›› 2021, Vol. 52 ›› Issue (2): 284-288.doi: 10.16098/j.issn.0529-1356.2021.02.019

• 组织学胚胎学发育生物学 • 上一篇    下一篇

高孕激素状态促排卵方案与其他3种促排卵方案体外受精-冻融周期的结果比较

李建华1 焦婷婷1 王建业1 李常山1 董攀1 陈曦2* 张水文1*   

  1. 1. 中国人民解放军总医院第七医学中心生殖医学科,北京 100700; 2. 北京大学人民医院生殖医学中心,北京 100044
  • 收稿日期:2020-03-27 修回日期:2020-05-11 出版日期:2021-04-06 发布日期:2021-04-06
  • 通讯作者: 陈曦;张水文 E-mail:zhang180308@163.com
  • 基金资助:
    miRNAs 调控优势卵泡选择及其影响小卵泡发育的分子机制

Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols

LI Jian-hua1 JIAO Ting-ting1 WANG Jian-ye1 LI Chang-shan1 DONG Pan1  CHEN Xi2* ZHANG Shui-wen1*    

  1. 1.Center of Reproductive Medicine and Genetics, the Seventh Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100700, China; 2.Center for Reproductive Medicine,Peking University Second Hospital,Beijing 100044,China
  • Received:2020-03-27 Revised:2020-05-11 Online:2021-04-06 Published:2021-04-06
  • Contact: CHEN Xi;ZHANG Shui-wen E-mail:zhang180308@163.com

摘要:

目的  比较高孕激素状态下促排卵(PPOS)方案与其他3种不同促排卵方案的实验室和临床妊娠结局。   方法  回顾性分析 2019年 6 月~ 2020 年 1 月在我院生殖中心行体外受精/卵泡浆内单精子显微注射(IVF/ICSI)共 430 个取卵周期和256个冻融周期,观察实验室相关数据、受精情况及妊娠结局的差异。   结果  取卵周期中,PPOS 方案 82 个,长方案 152个,短方案 116 个,拮抗剂方案 80 个。PPOS组获卵数(11.1±7.3)、受精率(85.6%)、卵裂率(95.1%)、可用胚胎数(4.5±3.1)、优质胚胎率(20.2%)等与其他3组之间差异均无统计学意义(P>0.05)。冻融周期中,PPOS 方案 27个周期,拮抗剂方案 107个,长方案 78 个,短方案 44 个。PPOS组种植率(26.2%)、临床妊娠率(63.0%)和流产率(11.8%)与其他各组比较差异无显著性(P>0.05),但临床妊娠率和种植率高于其他各组(P>0.05)。   结论  PPOS方案和其他3种促排卵相比,对卵泡发育、卵母细胞和胚胎质量没有影响,而且临床妊娠率和种植率有升高的趋势,可以作为常规促排卵方案的一种新的选择。

关键词: 控制性超促排卵, 高孕激素状态下促排卵方案, 冻融胚胎移植, 临床妊娠率, 体外受精, 卵泡浆内单精子显微注射, 女性

Abstract:

Objective  To analyze the clinical outcomes of progestin primed ovarian stimulation (PPOS) compared with the other three different controlled ovarian hyperstimulation (COH) protocols in fresh embryo transfer (ET) and frozen-thawed embryo transfer (FET) cycles.    Methods  A total of 430 oocyte pickup cycles and 272 FET cycles were retrospectively analyzed. Number of oocytes retrieved, laboratory indexes and pregnancy outcome of FET were compared.    Results  The mean oocytes retrieved (11.1±7.3), fertilization rate (85.6%), cleavage rate (95.1%) and excellent embryo rate (20.2%) as well as transplantable embryo rate (4.5±3.1) of the PPOS group did not show significant differences compared with the other 3 subgroups (all P<0.05) in fresh cycle. As for pregnancy outcomes in FET cycles, no statistically significant differences were observed among the four groups in embryo implantation rate (26.2%), clinical pregnancy rate (63.0%) and abortion rate (11.8%) (all P<0.05).However, embryo implantation rate, clinical pregnancy rate was higher in PPOS group compared with the other groups. Conclusion   Conclusion  Compared with the other three ovulation stimulation programme, PPOS might be used as a new alternative for controlled ovulation stimulation protocols.

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