Nogo蛋白与心肌纤维化关系的研究进展

doi:10.16098/j.issn.0529-1356.2022.05.021

摘要/Abstract

摘要：

Nogo蛋白是网状蛋白家族的第4个成员，编码基因转录产生的Nogo mRNA由于启动子和剪切方式不同形成3种不同的RNA转录体，分别为Nogo-A、Nogo-B和Nogo-C蛋白。Nogo蛋白最初在中枢神经系统中被发现，后证明广泛表达于心、肝和血管内皮等外周组织。研究表明，Nogo蛋白可通过RhoA/Rho相关激酶（ROCK）通路、内质网应激、Sce61α等多种信号通路参与心肌纤维化的调控过程。我们就Nogo-A、Nogo-B、Nogo-C与心肌纤维化的关系作简要介绍。

关键词: Nogo-A, Nogo-B, Nogo-C, 心肌纤维化

Abstract:

Nogo protein is the fourth member of reticulin family. Nogo mRNA produced by encoding gene transcription, forms three different RNA transcripts due to different promoter and splicing modes, namely Nogo-A, Nogo-B and Nogo-C protein. Nogo protein was first found in the central nervous system, and then proved to be widely expressed in peripheral tissues such as heart, liver and vascular endothelium. Studies have shown that Nogo protein can participate in the regulation of myocardial fibrosis through RhoA/Rho-associated kinase(ROCK) pathway, endoplasmic reticulum stress, Sce61 α and other signaling pathways. In this paper, the relationship between Nogo-A, Nogo-B, Nogo-C and myocardial fibrosis is briefly introduced.

Key words: Nogo-A, Nogo-B, Nogo-C, Myocardial fibrosis

中图分类号:

R331.3⁺1

胡耀文孙艳荣孙昊哲王文娟张苏欣秦丽华. Nogo蛋白与心肌纤维化关系的研究进展[J]. 解剖学报, 2022, 53(5): 674-679.

HU Yao-wen SUN Yan-rong SUN Hao-zhe WANG Wen-juan ZHANG Su-xin QIN Li-hua. Research progress on the relationship between Nogo protein and myocardial fibrosis[J]. Acta Anatomica Sinica, 2022, 53(5): 674-679.

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