阿尔茨海默病患者静息态下脑局部活动的多指标分析

doi:10.16098/j.issn.0529-1356.2023.01.011

解剖学报 ›› 2023, Vol. 54 ›› Issue (1): 75-81.doi: 10.16098/j.issn.0529-1356.2023.01.011

阿尔茨海默病患者静息态下脑局部活动的多指标分析

许琳¹ 刘晓丽¹ 陈争珍¹ 闻彩云² 李昌盛³ 李如画¹ 陈黛茜⁴ 陈成春1^*

1.温州医科大学基础医学院解剖学教研室，浙江温州 325000; 2.温州医科大学附属第一医院放射科，浙江温州 325000; 3.浙江大学医学院附属邵逸夫医院康复科，杭州 310000; 4.温州医科大学附属第一医院中医科，浙江温州 325000

收稿日期:2021-12-13 修回日期:2022-03-30 出版日期:2023-02-06 发布日期:2023-02-06
通讯作者: 陈成春 E-mail:liusw@sdu.edu.cn
作者简介:2022-05-01
基金资助:
成人大脑内静脉及其属支的 SWI 三维数字化构建;基于 SWI 显影深髓静脉形态改变对 TIA 患者发生缺血性脑卒中的预测价值研究;基于T2 mapping联合DTI技术的早期阿尔茨海默病内侧颞叶病变特征的研究

Multi-index analysis of regional brain activity in patients with Alzheimer’s disease during resting state

XU Lin¹ LIU Xiao-li¹ CHEN Zheng-zhen¹ WEN Cai-yun² LI Chang-sheng³ LI Ru-hua¹ CHEN Dai-qian⁴ CHEN Cheng-chun1^*

1.Department of Human Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Zhejiang Wenzhou 325000, China; 2.Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang Wenzhou 325000, China; 3.Department of Rehabilitation, Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China; 4.Department of Traditional Chinese Medicine, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang Wenzhou 325000, China

Received:2021-12-13 Revised:2022-03-30 Online:2023-02-06 Published:2023-02-06
Contact: CHEN Cheng-chun E-mail:liusw@sdu.edu.cn
Supported by:
The cerebral medullary venous networks visualization by susceptibility-weighted imaging;The research on the predictive value of ischemic stroke in TIA patients based on the morphological changes of deep medullary veins in SWI;Characteristics of medial temporal lobe lesions in early Alzheimer's disease based on T2 mapping combined with DTI

摘要/Abstract

摘要：

目的应用静息态功能磁共振(rs-fMRI)低频振幅(ALFF)、比率低频振幅(fALFF)和波动幅度百分比(PerAF)3种指标探究阿尔茨海默病(AD)患者脑部自发性神经活动特点。方法对36例AD患者和40例健康志愿者分别行静息态fMRI扫描，应用ALFF、fALFF和PerAF方法计算并对比两组脑区改变的差异。结果与正常对照组相比较，AD组在双侧尾状核、额内侧回、额上回、直回、前扣带回、嗅皮质，左侧额中回、额下回等区域mALFF值显著增高（P＜0.05）；在右侧颞中回、颞下回、枕下回、枕中回，双侧距状皮层、楔叶、舌回、枕上回、小脑蚓、楔前叶等区域mALFF值显著减低（P＜0.05）。AD组在右侧颞下回、小脑前叶、梭状回，左侧额上回、额内侧回、额中回、额下回、直回、前扣带回等区域mfALFF值显著增高（P＜0.05）；在双侧舌回，左侧距状皮层、楔叶、枕上回、枕中回、小脑蚓等区域mfALFF值显著减低（P＜0.05）。AD组在双侧直回、前扣带回、额内侧回，左侧额上回、尾状核、额中回、额下回、嗅皮质、脑岛等区域mPerAF值显著增高（P＜0.05）；在双侧距状皮层、楔叶、枕上回、舌回、楔前叶，左侧梭状回、枕下回，右侧顶上小叶、角回、颞中回、颞下回、枕中回等区域mPerAF值显著减低（P＜0.05）。结论 AD患者默认网络（DMN）和视觉网络存在异常脑活动特征，最显著的神经活动在前额叶皮层和视皮层区域。

关键词: 阿尔茨海默病, 低频振幅, 波动幅度百分比, 比率低频振幅, 静息态功能磁共振, 人

Abstract:

Objective To investigate the spontaneous neural activity in the brain of patients with Alzheimer’s disease (AD) used 3 indicators of resting state-functional magnetic resonance (rs-fMRI) amplitude of low frequency fluctuation (ALFF), fractional amplitude of low frequency fluctuation (fALFF) and percentage amplitude fluctuation (PerAF). MethodsTotally 36 clinically diagnosed AD patients and 40 healthy volunteers were scanned by fMRI in resting state respectively. ALFF, fALFF and PerAF were used to calculate and compare the changes of brain regions between the two groups. Results Compared with the normal control group, mALFF value in AD group increased significantly in bilateral caudate nucleus, medial frontal gyrus, superior frontal gyrus, gyrus rectus, anterior cingulate gyrus, olfactive cortex, left middle frontal gyrus and inferior frontal gyrus (P<0.05). mALFF values decreased significantly in the right middle temporal gyrus, inferior temporal gyrus, inferior occipital gyrus, middle occipital gyrus, bilateral calcarine, cuneus, lingual gyrus, superior occipital gyrus，vermis, precuneus and other regions (P<0.05). In AD group, mfALFF value of right inferior temporal gyrus, anterior cerebellar lobe, fusiform gyrus, left superior frontal gyrus, medial frontal gyrus, middle frontal gyrus, inferior frontal gyrus, gyrus rectus and anterior cingulate gyrus increased significantly (P<0.05); mfALFF values decreased significantly in bilateral lingual gyrus, left calcarine, cuneus, superior occipital gyrus, middle occipital gyrus and vermis (P<0.05). In AD group, mPerAF value incr eased significantly in bilateral gyrus rectus, anterior cingulate gyrus, medial frontal gyrus, left superior frontal gyrus, caudate nucleus, middle frontal gyrus, inferior frontal gyrus, olfactive cortex and insula (P<0.05); mPerAF values decreased significantly in bilateral calcarine, cuneus, superior occipital gyrus, lingual gyrus, precuneus, left fusiform gyrus, inferior occipital gyrus, right superior parietal lobule, angular gyrus, middle temporal gyrus, inferior temporal gyrus and middle occipital gyrus (P<0.05). Conclusion The default mode network (DMN) and visual network of AD patients are characterized by abnormal brain activity, with the most significant neural activity in the prefrontal cortex and visual cortex.

Key words:

Alzheimer’s disease, Amplitude of low frequency fluctuation, Fractional amplitude of low frequency fluctuation, Percentage amplitude fluctuation, Resting state-functional magnetic resonance, Human

中图分类号:

R455.2

许琳刘晓丽陈争珍闻彩云李昌盛李如画陈黛茜陈成春. 阿尔茨海默病患者静息态下脑局部活动的多指标分析[J]. 解剖学报, 2023, 54(1): 75-81.

XU Lin LIU Xiao-li CHEN Zheng-zhen WEN Cai-yun LI Chang-sheng LI Ru-hua CHEN Dai-qian CHEN Cheng-chun. Multi-index analysis of regional brain activity in patients with Alzheimer’s disease during resting state[J]. Acta Anatomica Sinica, 2023, 54(1): 75-81.

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阿尔茨海默病患者静息态下脑局部活动的多指标分析

Multi-index analysis of regional brain activity in patients with Alzheimer’s disease during resting state

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