AAS ›› 2015, Vol. 46 ›› Issue (5): 587-590.doi: 10.16098/j.issn.0529-1356.2015.05.002

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Nicotinamide adenine dinucleotide kinase 2 is highly expressed in malignant brain tumors

GAO Wei DONG Shi-ye PAN Fei-yan LIU Dan-hui*   

  1. School of Laboratory Medicine, and Life Sciences, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical University, Zhejiang Wenzhou 325035, China
  • Received:2015-04-14 Revised:2015-04-26 Online:2015-10-06 Published:2015-10-06
  • Contact: LIU Dan-hui E-mail:danhuiliu@outlook.com

Abstract:

Objective To investigate the nicotinamide adenine dinucleotide kinase 2 (NADK2) expression level in malignant brain tumors.Methods Immunohistochemistry analysis was used to analyze the NADK2 expression level in 75 malignant brain tumors including 55 of astrocytoma, 13 of oligodendroglioma, 3 of medulloblastoma and 4 of ependymoma. The integrated absorbance (IA) was measured by ImageJ software. Results The immunohistochemistry results showed that 74/75 tumor samples showed strong NADK2 staining. The IA results suggested that there was no significant difference between different brain tumor types as well as grades. Conclusion The results indicate that high expression of NADK2 is a general characteristic of malignant brain tumors.

Key words: Nicotinamide adenine dinucleotide kinase 2, Malignant brain tumors, Immunohistochemistry, Human