Polymorphism of leptin gene G-2548 A and pregnancy-induced hypertension syndrome in Han population of Qinghai Province

doi:10.16098/j.issn.0529-1356.2018.04.018

Abstract

Abstract:

Objective To investigate the relationship between polymorphism of leptin gene promoter region G-2548 A and pregnancy-induced hypertension syndrome（PIH）in Han population of Qinghai Province. Methods A total of 130 PIH subjects and 135 normal pregnancy subjects were studied. The genotype of leptin was analyzed by polymerase chain reaction fragment length polymorphism (PCR-RFLP). The mutation was confirmed by sequencing. Results The frequencies of leptin GG, GA, and AA genotype in the PIH group were 53.1%, 40% and 6.9%, and in the control group were 60%, 34.1% and 5.9% respectively. There was difference in frequency distribution of leptin genotype between the PIH and control groups. The frequency of G gene in the PIH group was higher than the control group (χ²=4.21，P<0.05，OR=0.66，95%CI=0.45-0.98). Conclusion Leptin gene G-2548 A is significantly correlated with PIH in Han group of QingHai. G allele may be a susceptible gene to PIH (OR=1.361, 95%CI: 1.01-1.83) and A allele may be a protective gene to PIH (OR=0.901, 95%CI: 0.82-1.00).

Key words: Qinghai Province, Pregnancy-induced hypertension syndrome, Leptin, Gene polymorphism, Gene frequency, PCR-RFLP, Pregnant woman

ZHUANG Wen-ting ZHAO De-xiong WANG Xiang-lin LI Hong-rong LI Chang-xing LI Fu-xin KONG De-xia LI Jian-hua. Polymorphism of leptin gene G-2548 A and pregnancy-induced hypertension syndrome in Han population of Qinghai Province[J]. Acta Anatomica Sinica, 2018, 49(4): 524-528.

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