Effects of remyelination of Olig on oligodendrocyte mediated demyelination in the rat

doi:10.3969/j.issn.0529-1356.2014.01.007

Abstract

Abstract:

Objective To investigate the role of oligodendrocytes mediated demyelination in the rat about Olig in myelin regeneration. Methods Forty healthy Wistar rats were randomly divided into normal group, model control group, model group and research group. Morphological observation and Immuno- histochemistry detection expression of Olig1 and Olig2 were performed. Results Olig1 was located the cytoplasm of oligodendrocytes in normal group, nuclear expression was increased significantly in model group, and Olig1 was retransferred to the cytoplasm in the research group. Expression of Olig2 was located in the nucleus in the normal group. A few of Olig2 were expressed in the cytoplasm in the model group. Conclusion The brain may not be able to generate oligodendrocytes when Oligl and Olig2 are deficient, which is affect of the myelin regeneration.

Key words: Olig1, Olig2, Oligodendrocyte, Remyelination, Bone marrow stromal cell, Transplantation, Immunohistochemistry, Rat

YAO Hong-bo ZHANG Meng GONG Xue-wu SUN Li-hui*. Effects of remyelination of Olig on oligodendrocyte mediated demyelination in the rat[J]. AAS, 2014, 45(1): 37-40.

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