Expression of 14-3-3zeta and p-Bad proteins in stage T1 non-small cell lung cancer and the significance

doi:10.3969/j.issn.0529-1356.2013.04.012

Abstract

Abstract:

Objective To observe the expression of 14-3-3zeta and p-Bad in stage T₁ non-small cell lung cancer(NSCLC), and to investigate the relationship between the expression of 14-3-3zeta and p-Bad in NSCLC. Methods One hundred and ten paraffin
blocks and 50 fresh samples from NSCLC patients and normal lung were observed. Expression of 14-3-3zeta and p-Bad were detected by immunohistochemistry and Western blotting. Results Up-regulation of 14-3-3zeta was observed significantly in stage T₁ NSCLC
in contrast to that in the normal lung. The increased 14-3-3zeta protein level was correlated with differentiation degree and lymph node metastasis, but it was disassociated with age, gender and histological type. Decreased expression of p-Bad was observed
in NSCLC in contrast to that in the normal lung. Expression of p-Bad was related to differentiation degree and lymph node metastasis, but it was disassociated with age, gender and histological type. Conclusion 14-3-3zeta and p-Bad play an important role in
development and progression of NSCLC.

Key words: Non-small cell lung cancer, 14-3-3zeta, p-Bad, Western blotting, Human

CLC Number:

R734.2

ZANG Dong-yu* LI Fu-zhi YANG Chun-yu. Expression of 14-3-3zeta and p-Bad proteins in stage T₁ non-small cell lung cancer and the significance[J]. AAS, 2013, 44(4 ): 509-513.

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Expression of 14-3-3zeta and p-Bad proteins in stage T₁ non-small cell lung cancer and the significance

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