Recent progress on the mechanism of energy metabolism of hypoxia-inducible factor 1-driven skeletal muscle adaptations to hypoxia

doi:10.16098/j.issn.0529-1356.2017.02.021

Abstract

Abstract:

Hypoxia-inducible factor1 (HIF-1) is a key nuclear transcription factor that regulates the oxygen homeostasis of tissue cells and widely exists in both mammals and humans. The expression and activity of HIF-1 are tightly regulated by cellular oxygen concentration. It can regulate the biological effects of cellular energy metabolism, angiogenesis, erythropoiesis, cell survival, cell proliferation and apoptosis in the physiological and pathological hypoxic-ischemic condition, so that the cells can adapt to the hypoxic environment to survive, or to apoptosis. This paper reviewed the structure and function of HIF-1 and the recent progress on the study of the mechanism of energy metabolism of HIF-1-driven skeletal muscle adaptations to hypoxia.

Key words: Hypoxia, Hypoxia-inducible factor 1, Skeletal muscle, Energy metabolism

SONG Ya-qiong ZHOU Bo-jiang. Recent progress on the mechanism of energy metabolism of hypoxia-inducible factor 1-driven skeletal muscle adaptations to hypoxia[J]. Acta Anatomica Sinica, 2017, 48(2): 236-240.

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