›› 2011, Vol. 42 ›› Issue (4): 451-455.doi: 10.3969/j.issn.0529-1356.2011.04.004
• 神经生物学 • 上一篇 下一篇
蒋吉英1*; 姜桂兰2 ;李磊1;赵金岭1;史才兴1;于树娜1;齐安东1
收稿日期:
修回日期:
出版日期:
通讯作者:
Received:
Revised:
Online:
Contact:
关键词: N-乙酰-L-色氨酸, 脑, 缺血/缺氧损伤, 免疫荧光, 免疫印迹法, 新生沙土鼠
Abstract: Objective To investigate the possible neuroprotective effects of N-acetyl-L-tryptophan（L-NAT） in cerebral ischemia/hypoxia injury. Methods The ischemia/hypoxia injury models were made in 90 pups of seven days old gerbil.The death of neurons was evaluated by Fluoro-Jade B（FJB）staining and the activations of Caspase-9 and Caspase-3 were evaluated by immunofluorescent staining and Western blotting. Results Our results showed that L-NAT treatment decreased the number of FJB positive cells after middle cerebral artery occlusion in mice. And L-NAT also inhibited the expressions of Caspase-3 and Caspase-9. Conclusion Our work demonstrated that L-NAT had
Key words: N-acetyl-L-tryptophan, Brain, Ischemia/hypoxia injury, Immunofluorescence, Western blotting, Newborn gerbil
中图分类号:
R743.3
蒋吉英;姜桂兰 ;李磊;赵金岭;史才兴;于树娜;齐安东. N-乙酰-L-色氨酸具有对新生鼠脑缺血/缺氧损伤的保护作用 [J]. , 2011, 42(4): 451-455.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: https://jpxb.bjmu.edu.cn/CN/10.3969/j.issn.0529-1356.2011.04.004
https://jpxb.bjmu.edu.cn/CN/Y2011/V42/I4/451
酒精性肝纤维化核因子κB信号通路与性别的差异
大鼠颈上神经节中Ⅰ组代谢型谷氨酸受体表达及慢性间歇性低氧对其的影响
多发性硬化和视神经脊髓炎的脑灰质结构分析
三七总皂苷抑制小鼠星形胶质细胞活化缓解完全弗氏佐剂所致炎性痛
抑制lncRNA TUG1下调核苷酸结合寡聚结构域样受体蛋白1炎症小体在延缓阿尔茨海默病进展的作用
创伤性颅脑损伤中神经功能障碍与认知功能损伤的动态变化
松茸多糖对 1-甲基-4-苯基-吡啶离子诱导 PC12 细胞损伤的影响
脑源性神经营养因子在牦牛与黄牛端脑不同区域的表达与分布
高龄大鼠心室肌间质弹性纤维和胶原纤维的结构分布特征及其机制
白细胞介素6对脂多糖诱导所致类子痫前期大鼠有核红细胞的影响
