解剖学报 ›› 2015, Vol. 46 ›› Issue (5): 699-703.doi: 10.16098/j.issn.0529-1356.2015.05.022

• 综述 • 上一篇    下一篇

不同分化阶段诱导性多能干细胞移植实验研究进展

李君 杜潇 吴嫣爽 雷蕾*   

  1. 哈尔滨医科大学组织学与胚胎学教研室, 黑龙江 哈尔滨 150081
  • 收稿日期:2015-03-03 修回日期:2015-05-11 出版日期:2015-10-06 发布日期:2015-10-06
  • 通讯作者: 雷蕾 E-mail:leiys2002@yahoo.com
  • 基金资助:

    国家重点基础研究发展计划

Transplantation studies of induced pluripotent stem cells at different differentiated stages

LI Jun DU Xiao WU Yan-shuang LEI Lei*   

  1. Department of Histology and Embryology,Harbin Medical University,Harbin 150081,China
  • Received:2015-03-03 Revised:2015-05-11 Online:2015-10-06 Published:2015-10-06

摘要:

诱导性多能干细胞(iPSCs)是由动物体细胞重编程得到的具有胚胎干细胞特性的全能干细胞。近年来,随着多能干细胞诱导技术的不断优化以及体外分化技术的飞速发展,多种分化状态的多能干细胞被用于移植实验。我们结合最新研究进展,阐述各种分化阶段诱导性多能干细胞用于动物移植治疗的优缺点,以及最新移植方法所存在的问题。  

关键词: 诱导性多能干细胞, 囊胚互补, 器官芽

Abstract:

Induced pluripotent stem cells (iPSCs) which derived from reprogrammed somatic cells, are totipotential cells similar to embryonic stem cells. Recently, iPSCs technology has been promptly improved in methods of induction and in vitro differentiation. Consequently, iPSCs at different differentiated stages have been widely studied in cell transplantation experiments. Here, we summarize the current studies of iPSCs transplantation, and reviewe some novel methods comparing with the older one. We propose that some problems need to be resolved before iPSCs could be applied in clinic therapy.

Key words: induced pluripotent Induced pluripotent stem cell, Blastocyst complementation, Organ bud