雄激素及其受体与多囊卵巢综合征

doi:10.16098/j.issn.0529-1356.2018.01.023

解剖学报 ›› 2018, Vol. 49 ›› Issue (1): 132-136.doi: 10.16098/j.issn.0529-1356.2018.01.023

• 综述 • 上一篇

雄激素及其受体与多囊卵巢综合征

杨玫^1,2 林海伟¹ 张宏权²徐小明^1* 陈曦^3*

1. 北京家圆医院生殖医学中心，北京 100034; 2. 北京大学医学部基础医学院组织学与胚胎学教研室，北京 100191; 3. 北京大学人民医院生殖医学中心，北京 100044

收稿日期:2017-02-13 修回日期:2017-04-06 出版日期:2017-02-06 发布日期:2018-02-06
通讯作者: 徐小明;陈曦 E-mail:bjpfh_xxm@163.com
基金资助:
北京大学人民医院教育教学研究课题

Androgen, androgen receptor and polycystic ovary syndrome

YANG Mei ^1,2 LIN Hai-wei¹ ZHANG Hong-quan² XU Xiao-ming ^1* CHEN Xi ^3*

1. Center for Reproductive Medicine, Beijing Perfect Family Hospital, Beijing 100034, China; 2. Department of Histology and Embryology, School of Basic Medicine, Peking University, Beijing 100191, China; 3. Center for Reproductive Medicine, Peking University Second Hospital, Beijing 100044, China

Received:2017-02-13 Revised:2017-04-06 Online:2017-02-06 Published:2018-02-06
Contact: XU Xiao-ming;CHEN Xi E-mail:bjpfh_xxm@163.com

摘要/Abstract

摘要：

多囊卵巢综合征（PCOS）是育龄期妇女常见的一种内分泌代谢性疾病，发病率为5%～10%，其发病机制尚未完全阐明。高雄激素血症是PCOS的突出特点，尤其是卵巢局部的高雄激素环境是导致PCOS的关键原因，因此对高雄激素形成这一特征性改变的研究成为阐明PCOS病因的重点所在。雄激素主要通过激活雄激素受体（AR）来发挥作用，故AR的作用不容忽视，我们着重就雄激素和AR在PCOS发病中的作用作一综述。

关键词: 雄激素, 雄激素受体, 高雄激素血症, 多囊卵巢综合征

Abstract:

Polycystic ovary syndrome (PCOS), with a prevalence of 5%-10%, is the most common endocrine and metabolic dysfunction of reproductive age women. However, the underlying mechanism has not been fully elucidated. Hyperandrogenism is the leading defect in PCOS patients, especially local androgen secretion by the ovary is the key element for PCOS pathogenesis. Androgen activates androgen receptor (AR), so the role of AR is an indispensable factor. This review focuses on the functions of androgen and AR in PCOS pathogenesis.

Key words: Androgen, Androgen receptor, Hyperandrogenism, Polycystic ovary syndrome

杨玫林海伟张宏权徐小明陈曦. 雄激素及其受体与多囊卵巢综合征[J]. 解剖学报, 2018, 49(1): 132-136.

YANG Mei LIN Hai-wei ZHANG Hong-quan XU Xiao-ming CHEN Xi. Androgen, androgen receptor and polycystic ovary syndrome[J]. Acta Anatomica Sinica, 2018, 49(1): 132-136.

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雄激素及其受体与多囊卵巢综合征

Androgen, androgen receptor and polycystic ovary syndrome

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