瞬时感受器电位香草酸受体1在变应性鼻炎鼻黏膜中的作用机制

doi:10.16098/j.issn.0529-1356.2018.06.027

摘要/Abstract

摘要：

瞬时感受器电位香草酸受体1（TRPV1）通道是一种非选择性阳离子通道，其可以被辣椒素、高温等多种刺激因素激活，参与多种生理及病理过程。最新研究证实，TRPV1离子通道是神经-免疫调控网络机制的核心要素，在变应性鼻炎鼻黏膜中发挥重要作用。我们通过对TRPV1经神经-免疫调控网络调节神经肽，进而影响鼻部症状的研究进展做简要综述，期望为临床治疗变应性鼻炎提供理论依据。

关键词: 瞬时感受器电位香草酸受体1, 变应性鼻炎, 鼻黏膜, 神经-免疫调控网络, 鼻部症状

Abstract:

Transient receptor potential vanilloid 1(TRPV1) pathway is a non selective cation pathway, which can be activated by various stimulators such as capsaicin and high temperature, and participate in many physiological and pathological processes. As is confirmed by the latest research that the TRPV1 pathway is a core factor of mechanism of nerve immune regulation network, which plays an important role in nasal mucosa in allergic rhinitis. This article is a brief review about the research progress of TRPV1 regulating and controling neuropeptides by neural immunoregulation network which could influence the symptoms of nasal mucosa. It is expected to provide theoretical basis for clinical treatment of allergic rhinitis.

Key words: Transient receptor potential vanilloid 1, Allergic rhinitis, Nasal mucosa, Neuro-immune regulation network, Nasal symptom

刘莉莉刘建华矫璐璐刘思溟巩政张琳琳边芳子张琳婧闫占峰刘巧平. 瞬时感受器电位香草酸受体1在变应性鼻炎鼻黏膜中的作用机制[J]. 解剖学报, 2018, 49(6): 852-857.

LIU Li-li LIU Jian-hua JIAO Lu-lu LIU Si-ming GONG Zheng ZHANG Lin-lin BIAN Fang-zi ZHANG Lin-jing YAN Zhan-feng LIU Qiao-ping. Mechanism of transient receptor potential vanilloid 1 in nasal mucosa of allergic rhinitis[J]. Acta Anatomica Sinica, 2018, 49(6): 852-857.

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