多肽-N乙酰氨基半乳糖转移酶10在肺癌中的表达及意义

doi:10.16098/j.issn.0529-1356.2020.02.009

解剖学报 ›› 2020, Vol. 51 ›› Issue (2): 206-210.doi: 10.16098/j.issn.0529-1356.2020.02.009

多肽-N乙酰氨基半乳糖转移酶10在肺癌中的表达及意义

蔡翠霞高媛刘玥王涵多*

南方医科大学基础医学院，广东省生物芯片重点实验室，广州 510515

收稿日期:2019-01-03 修回日期:2019-04-08 出版日期:2020-04-06 发布日期:2020-04-06
通讯作者: 王涵多 E-mail:wanghanduo0690@163.com

Expression of polypeptide N-acetylgalactosaminyltransferase-10 in lung cancer#br#

CAI Cui-xia GAO Yuan LIU Yue WANG Han-duo*

School of Basic Medical Science, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou 510515, China

Received:2019-01-03 Revised:2019-04-08 Online:2020-04-06 Published:2020-04-06
Contact: WANG Han-duo E-mail:wanghanduo0690@163.com

摘要/Abstract

摘要：

目的探讨检测多肽-N乙酰氨基半乳糖转移酶10（pp GalNAc-T10）单细胞技术与应用蛋白在肺癌、乳腺癌和结肠癌中的表达。方法采用免疫组织化学检测ppGalNAc-T10在110例肺癌组织、100例乳腺癌组织和110例结肠癌组织中的表达；不同的肿瘤均有10例相对应的正常组织作为对照。结果同正常肺组织相比较，ppGalNAc-T10在肺癌组织中表达较低；且ppGalNAc-T10的表达与肿瘤侵袭深度相关(P<0.01)。PpGalNAc-T10蛋白在乳腺癌和结肠癌及其相对应的正常组织的表达差异无显著性。结论 PpGalNAc-T10在肺癌中，有可能成为的1个有效标记蛋白。

关键词: 肺癌, 乳腺癌, 结肠癌, 多肽-N乙酰氨基半乳糖转移酶10, 人

Abstract:

Objective The purpose of this study is to investigate the expression of the polypeptide N-acetylgalactosaminyltransferase-10(ppGalNAc-T10) protein in lung and breast and colon cancer. Methods Immunohistochemistry was used to analyse ppGalNAc-T10 expressions in 110 lung cancer tissues, 100 breast cancer tissues and 110 colon cancer tissues. Meanwhile, different cancer has 10 cases of normal tissues as control. Results The expression of ppGalNAc-T10 in normal lung tissue was higher compared with that in lung cancer organizations, and ppGalNAc-T10 positive expression was found to be significantly associated with invasion depth of tumor (P<0.01). PpGalNAc-T10 protein expression in breast and colon cancer was no significantly difference than that in non-tumor breast and colon tissue. Conclusion PpGalNAc-T10 expression is a useful marker in lung cancer.

Key words: Lung cancer, , Breast cancer, , Colon cancer, , Polypeptide N-acetylgalactosaminyltransferase-10, Human

中图分类号:

R735.1

蔡翠霞高媛刘玥王涵多. 多肽-N乙酰氨基半乳糖转移酶10在肺癌中的表达及意义[J]. 解剖学报, 2020, 51(2): 206-210.

CAI Cui-xia GAO Yuan LIU Yue WANG Han-duo. Expression of polypeptide N-acetylgalactosaminyltransferase-10 in lung cancer#br#[J]. Acta Anatomica Sinica, 2020, 51(2): 206-210.

参考文献

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多肽-N乙酰氨基半乳糖转移酶10在肺癌中的表达及意义

Expression of polypeptide N-acetylgalactosaminyltransferase-10 in lung cancer#br#

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