下丘脑弓状核KNDy神经元参与围绝经期潮热发生的机制

doi:10.16098/j.issn.0529-1356.2021.06.025

摘要/Abstract

摘要：

潮热是围绝经期女性最常见的特异性症状，严重危害女性的身心健康和生活质量。由于潮热的发病机制尚未明确，且现有的雌激素替代疗法存在诸多局限和禁忌，故探讨潮热的发病机制并寻找新的治疗靶点尤为迫切和重要。近年研究提示，围绝经期雌激素降低时下丘脑弓状核（ARC）中KNDy神经元异常是引起潮热的关键因素。部分学者认为，ARC中KNDy神经元通过调控促性腺激素释放激素及其下游促黄体生成素的脉冲释放参与潮热的发生；而另有学者认为，ARC中KNDy神经元通过调控下丘脑视前区的正中视前核在潮热发生过程中发挥关键作用。我们就上述两种关于ARC KNDy神经元与潮热发生之间的关系及其参与潮热的可能机制进行总结和概括，为探寻诊治围绝经期潮热的新靶点和新方法奠定理论基础。

关键词: KNDy神经元, 弓状核, 促黄体生成素, 促性腺激素释放激素, 正中视前核, 视前区, 潮热, 围绝经期, 女性

Abstract:

Hot flashes are the most common specific symptom of perimenopausal women, which seriously endangers their physical and mental health and quality of life. Because the pathogenesis of hot flashes is not yet clear, and existing estrogen replacement therapy has many limitations and contraindications, it is particularly urgent and important to explore the pathogenesis of hot flashes and find new therapeutic targets. Recent studies suggest that abnormalities of KNDy neurons in the arcuate nucleus of hypothalamus when estrogen decreases during perimenopause are the key factors that trigger hot flashes. Some scholars believe that KNDy neurons in the arcuate nucleus are involved in the occurrence of hot flashes by regulating the pulse release of gonadotropin-releasing hormone and its downstream luteinizing hormone, while some other scholars believe that KNDy neurons in the arcuate nucleus play a key role in the process of hot flashes by regulating the median preoptic nucleus of the hypothalamic preoptic are a. Therefore, this review intends to summarize the above two types of current relationship between the KNDy neurons in the arcuate nucleus and the occurrence of hot flashes and the possible mechanisms by which KNDy neurons participate in hot flashes, and lay a theoretical foundation for the exploring of new targets and method for the treatment of perimenopausal hot flashes.

Key words: KNDy neuron, Arcuate nucleus, Luteinizing hormone, Gonadotropin-releasing hormone, Median preoptic nucleus, Preoptic area, Hot flash, Perimenopause, Female

中图分类号:

R711.75

孙艳荣戴立新王文娟王珂秦丽华 . 下丘脑弓状核KNDy神经元参与围绝经期潮热发生的机制[J]. 解剖学报, 2021, 52(6): 992-998.

SUN Yan-rong Dai Li-xin WANG Wen-juan WANG Ke QING Li-hua. Mechanism of KNDy neurons in arcuate nucleus of hypothalamus involved in the occurrence of perimenopausal hot flashes[J]. Acta Anatomica Sinica, 2021, 52(6): 992-998.

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