解剖学报

解剖学报 ›› 2024, Vol. 55 ›› Issue (1): 62-66.doi: 10.16098/j.issn.0529-1356.2024.01.009

• 细胞和分子生物学 • 上一篇    下一篇

 宁夏大学生示指和环指指长比与同源盒A11基因位点多态性的关联性

 杨梦怡 牛世博 张静 党洁 马占兵 陆宏* 霍正浩*   

  1. 宁夏医科大学基础医学院教育部生育力保持省部共建重点实验室，银川 750004
  • 收稿日期:2022-08-12 修回日期:2022-10-09 出版日期:2024-02-06 发布日期:2024-02-06
  • 通讯作者: 陆宏 霍正浩 E-mail:chuan773@126.com
  • 基金资助:
    国家自然科学基金

 Association between index finger and ring finger length ratios and polymorphism of homeobox A11 gene locus among Ningxia college students

 YANG  Meng-yi  NIU  Shi-bo  ZHANG  Jing  DANG  Jie  MA  Zhan-bing  LU  Hong*  HUO  Zheng-hao*   

  1. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Basic Medical College, Ningxia Medical University, Yinchuan 750004, China
  • Received:2022-08-12 Revised:2022-10-09 Online:2024-02-06 Published:2024-02-06
  • Contact: LU Hong HUO Zheng-hao E-mail:chuan773@126.com

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摘要：

目的  探讨宁夏大学生示指和环指指长比（2D∶4D）与同源盒（HOX）A11基因4个位点（rs6461992、rs6968828、rs7801581、rs17427875）多态性的关联性。   方法  采用数码相机提取667名宁夏汉族大学生（男性348名，女性319名）手部正面照片，图像分析软件标记解剖点并测量双手示指及环指指长；多重PCR法检测HOXA11基因各位点多态性；统计学软件比较分析2D∶4D和基因多态性在不同性别间的差异及其关联。  结果  宁夏汉族大学生女性左手和右手2D∶4D均显著高于男性（均P<0.05），右手-左手2D∶4D性别差异不显著；HOXA11基因rs7801581位点基因型、等位基因频率在不同性别间差异显著（均P<0.05），其他位点多态性在性别间的差异均无统计学意义；2D∶4D与HOXA11基因位点多态性关系中，仅女性左手 2D∶4D与 rs6461992位点基因型显著关联（P<0.05）。  结论  宁夏汉族大学生2D∶4D性别间差异显著，HOXA11基因rs6461992位点多态性可能与女性 2D∶4D 的形成有关。

 

关键词:

  同源盒A11基因, 示指, 环指, 指长比, 多重聚合酶链反应, 宁夏大学生

Abstract:

Objective  To investigate the association between the index finger and ring finger length ratio (2D∶4D) and of four loci (rs6461992, rs6968828, rs7801581, rs17427875) polymorphism of homeobox (HOX) A11 gene among Ningxia college students.   Methods  Digit camera was used to collect frontal hand photos of 667 Han college students (348 males and 319 females) from Ningxia province; Image analysis software was used to mark the anatomical points and measure finger lengths of the index and ring fingers of both hands; multiplex PCR was used to detect each locus polymorphisms of HOXA11 gene; statistical software was used to compare and analyze the differences and associations of 2D∶4D and gene polymorphisms between different genders.   Results  Among Ningxia Han college students, both left hand and right hand 2D∶4D were significantly higher in females than those of in males (all P<0.05), and there were no significant sex differences in right-left hand 2D∶4D; the genotypes and allele frequencies of rs7801581 locus of HOXA11 gene differed significantly between genders (all P<0.05), and none of the other locus polymorphisms showed any significant sex differences; only female left hand 2D∶4D was significantly associated with rs6461992 locus genotype in the relationship between 2D∶4D and HOXA11 polymorphisms (P<0.05).   Conclusion  There were significant sex differences in 2D∶4D among Han college students in Ningxia, and the rs6461992 locus polymorphism of HOXA11 gene may be associated with the formation of 2D∶4D in females.

Key words: Homeobox A11 gene, Index finger, Ring finger, Digit ratio, Multiplex PCR, Ningxia college student

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