N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布

doi:10.3969/j.issn.0529-1356.2013.04.003

解剖学报 ›› 2013, Vol. 44 ›› Issue (4 ): 456-462.doi: 10.3969/j.issn.0529-1356.2013.04.003

N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布

毕文杰¹ 肖莉¹ 郑翔^2*

1. 成都医学院解剖学教研室，成都 610083; 2. 四川大学华西基础医学与法医学院基础医学专业实验室，成都 610041

收稿日期:2012-05-07 修回日期:2012-08-13 出版日期:2013-08-06 发布日期:2013-09-04
通讯作者: 郑翔 E-mail:jasondf211@163.com
基金资助:
成都医学院校基金课题（CYZ09-006）

N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats

BI Wen-jie¹ XIAO Li¹ ZHENG Xiang^2*

1. Department of Anatomy, Chengdu Medical College, Chengdu 610083,China; 2. Laboratory of Preclinical Medicine,West China School of Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China

Received:2012-05-07 Revised:2012-08-13 Online:2013-08-06 Published:2013-09-04

摘要/Abstract

摘要：

目的获取大鼠脑部的N-甲基-D-天门冬氨酸受体2A（NMDAR _2A）表达强度分布的数据。方法通过免疫组织化学染色和图像分析，对成年雄性SD大鼠（n=6）不同脑区的NMDAR _2A表达进行检测。结果得到大鼠全脑各主要结构NMDAR _2A表达强度的数据，并绘制图谱。结论
获得的NMDAR _2A表达图谱可为原位检测鼠脑NMDAR _2A的实验提供参考。

关键词: 脑, N-甲基-D-天门冬氨酸受体2A, 免疫组织化学, 大鼠

Abstract:

Objective N-methyl-D-aspartate receptor (NMDAR) is an important excitatory receptor within the central nervous system. Its 2A subunit is a critical functional subunit. There is no comprehensive data about NMDAR _2A expression intensity
in rat brain. Methods In this experiment, we detected NMDAR _2Aexpression in the brain of adult male SD rat (n=6) with immunohistochemistry staining and image analysis. Results We drew the expression intensity atlas of rat brain based on the
immunohistochemical staining intensity. Conclusion These data can provide a reference for in situ detection of NMDAR _2Ain related experiments.

Key words: Brain, N-methyl-D-aspartate receptor 2A, Immunohistochemistry, Rat

中图分类号:

R322.8-3

毕文杰肖莉郑翔* . N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布[J]. 解剖学报, 2013, 44(4 ): 456-462.

BI Wen-jie XIAO Li ZHENG Xiang* . N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats[J]. AAS, 2013, 44(4 ): 456-462.

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N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布

N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats

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