解剖学报 ›› 2014, Vol. 45 ›› Issue (3): 430-436.doi: 10.3969/j.issn.0529-1356.2014.03.025
牛苗苗 战军* 张宏权
收稿日期:
2013-11-05
修回日期:
2013-12-12
出版日期:
2014-06-06
发布日期:
2014-06-06
通讯作者:
战军
E-mail:zhanjun@bjmu.edu.cn
基金资助:
国家自然科学基金资助项目
NIU Miao-miao ZHAN Jun* ZHANG Hong-quan
Received:
2013-11-05
Revised:
2013-12-12
Online:
2014-06-06
Published:
2014-06-06
Contact:
ZHAN Jun
E-mail:zhanjun@bjmu.edu.cn
摘要:
HOX基因是同源异形盒基因家族的一个亚家族,在进化上高度保守。HOX基因编码的蛋白是一类重要的转录因子,在胚胎发育中调节多个过程,包括细胞的生长、分化、凋亡、运动和血管生成等。近年来的研究发现,HOX基因的异常表达与恶性肿瘤密切相关。我们就有关HOX基因在肿瘤发生发展中的研究进展进行以下综述。
牛苗苗 战军* 张宏权. HOX基因在肿瘤发生发展中的作用[J]. 解剖学报, 2014, 45(3): 430-436.
NIU Miao-miao ZHAN Jun* ZHANG Hong-quan. Role of HOX genes in tumor genesis and development[J]. AAS, 2014, 45(3): 430-436.
[1]ShahN, Sukumar S. The Hox genes and their roles in oncogenesis[J]. Nat Rev Cancer, 2010,10(5): 361-371. [2]Grier DG, Thompson A, Kwasniewska A, et al. The pathophysiolo-gy of HOX genes and their role in cancer[J]. J Pathol, 2005,205(2): 154-171. [3]Calvo R, West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer[J]. Proc Natl Acad Sci USA,2000,97(23): 12776-12781. [4]Ohta H, Hamada J,Tada M, et al. HOXD3-overexpression increases integrin αvβ3 expression and deprives E-cadherin while it enhances cell motility in A549 cells[J]. Clin Exp Metastasis,2006, 23(7-8): 381-390. [5]Nguyen DX, Chiang AC, Zhang X, et al. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis[J]. Cell,2009,138(1): 51-62. [6]Inamura K, Togashi Y, Ninomiya H, et al. HOXB2, an adverse prognostic indicator for stage I lung adenocarcinomas, promotes invasion by transcriptional regulation of metastasis-related genes in HOP-62 non-small cell lung cancer cells[J]. Anticancer Res,2008,28(4B): 2121-2127. [7]Rauch T, Wang Z, Zhang X, et al. Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay[J]. Proc Natl Acad Sci USA,2007,104(13): 5527-5532. [8]Kim DS, Kim MJ, Lee JY, et al. Epigenetic inactivation of homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features[J]. Mol Carcinog,2009,48(12): 1109-1115. [9]Plowright L, Harrington KJ, Pandha HS, et al. HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer) [J]. Br J Cancer, 2009,100(3): 470-475. [10]Takahashi O, Hamada J, Abe M, et al. Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma[J]. Oncol Rep, 2007,17(4): 753-760. [11]Liu DB, Gu ZD, Cao XZ, et al. Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomas[J]. World J Gastroenterol,2005,11(10): 1562-1566. [12]Lü J, Cao XF, Ji L, et al. Association of β-catenin, Wnt1, Smad4, Hoxa9, and Bmi-1 with the prognosis of esophageal squamous cell carcinoma[J]. Med Oncol, 2012,29(1): 151-160. [13]Gu ZD, Shen LY, Wang H, et al. HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma[J]. Cancer Res,2009,69(12): 4969-4973. [14]Han Y, Tu WW, Wen YG, et al. Identification and validation that up-expression of HOXA13 is a novel independent prognostic marker of a worse outcome in gastric cancer based on immunohistochemistry[J]. Med Oncol,2013,30(2): 564. [15]Sha S, Gu Y, Xu B, et al. Decreased expression of HOXB9 is related to poor overall survival in patients with gastric carcinoma[J]. Dig Liver Dis,2013, 45(5):422-429. [16]Kanai M, Hamada J, Takada M, et al. Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas[J]. Oncol Rep,2010,23(3): 843-851. [17]Ghoshal K, Motiwala T, Claus R, et al. HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors[J]. PLoS One,2010,5(4): e10338-e10338. [18]Jung C, Kim RS, Zhang H, et al. HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation[J]. Br J Cancer,2005,92(12): 2233-2239. [19]Vider BZ, Zimber A, Chastre E, et al. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines[J]. Biochem Biophys Res Commun,2000,272(2): 513-518. [20]Wu X, Chen H, Parker B, et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition[J]. Cancer Res,2006,66(19): 9527-9534. [21]Chiba N, Comaills V, Shiotani B, et al. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses[J]. Proc Nati Acad Sci USA,2012,109(8): 2760-2765. [22]Seki H, Sakata M, Takahashi M, et al. HOXB9 Expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients[J]. Ann Surg Oncol,2012,19(6): 1831-1840. [23]Zhang X, Zhu T, Chen Y, et al. Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene[J]. J Biol Chem,2003,278(9): 7580-7590. [24]Shaoqiang C, Yue Z, Yang L, et al. Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer[J]. Clin Exp Metastasis,2013,30(2): 155-163. [25]Carrio M, Arderiu G, Myers C, et al. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model[J]. Cancer Res,2005,65(16): 7177-7185.[26]Raman V, Martensen SA, Reisman D, et al. Compromised HOXA5 function can limit p53 expression in human breast tumours[J]. Nature,2000,405(6789): 974-978. [27]Duriseti S, Winnard JP, Mironchik Y, et al. HOXA5 regulates hMLH1 expression in breast cancer cells[J]. Neoplasia,2006,8(4): 250-258. [28]Chen H, Zhang H, Lee J, et al. HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition[J]. Cancer Res,2007,67(17): 8007-8013. [29]Chen H, Chung S, Sukumar S. HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8[J]. Mol Cell Biol,2004,24(2): 924-935. [30]Sun M, Song CX, Huang H, et al. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis[J]. Proc Natl Acad Sci USA, 2013,110(24): 9920-9925. [31]Gilbert PM, Mouw JK, Unger MA, et al. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype[J]. J Clin Invest, 2010,120(5): 1535-1550. [32]Chu MC, Selam FB, Taylor HS. HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells[J]. Cancer Biol Ther,2004,3(6): 568-572. [33]Habel LA, Sakoda LC, Achacoso N, et al. HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease[J]. Breast Cancer Res,2013,15(2): R24. [34]Li B, Jin H, Yu Y, et al. HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival[J]. Int J Gynecol Cancer,2009,19(8): 1347-1352. [35]Matei DE, Nephew KP. Epigenetic therapies for chemoresensitiza-tion of epithelial ovarian cancer[J]. Gynecol Oncol,2010,116(2): 195-201. [36]Naora H, Montz FJ, Chai CY, et al. Aberrant expression of homeobox gene HOXA7 is associated with müllerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response[J]. Proc the Natl Acad Sci USA,2001,98(26): 15209-15214. [37]Miao J, Wang Z, Provencher H, et al. HOXB13 promotes ovarian cancer progression[J]. Proc Natl Acad Sci USA,2007,104(43): 17093-17098. [38]Klausen C, Leung PC, Auersperg N. Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin[J]. Mol Cancer Res,2009,7(9): 1425-1437. [39]Morgan R, Plowright L, Harrington K J, et al. Targeting HOX and PBX transcription factors in ovarian cancer[J]. BMC Cancer,2010,10: 89. [40]Jung C, Kim RS, Lee SJ, et al. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4[J]. Cancer Res,2004,64(9): 3046-3051. [41]Kim SD, Park RY, Kim YR, et al. HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression[J]. Anat Cell Biol,2010,43(4): 284-293. [42]Norris JD, Chang CY, Wittmann BM, et al. The homeodomain protein HOXB13 regulates the cellular response to androgens[J]. Mol Cell,2009,36(3): 405-416. [43]Ren G, Zhang G, Dong Z, et al. Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers[J]. Int J Biochem Cell Biol,2009,41(5): 1094-1101. [44]Kim YR, Oh KJ, Park RY, et al. Research HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling[J]. Mol Cancer, 2010, 9: 124. [45]Chen Z, Greenwood C, Isaacs WB, et al. The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial[J]. Carcinogenesis,2013,34(6): 1260-1264. [46]Jeong TO, Oh KJ, Nguyen X, et al. Evaluation of HOXB13 as a molecular marker of recurrent prostate cancer[J]. Mol Med Rep,2012,5(4): 901-904. [47]Miller GJ, Miller HL, van Bokhoven A, et al. Aberrant HOXC expression accompanies the malignant phenotype in human prostate[J]. Cancer Res,2003,63(18): 5879-5888. [48]McCabe CD, Spyropoulos DD, Martin D, et al. Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer[J]. Cancer Res,2008,68(6): 1988-1996. [49]Axlund SD, Lambert JR, Nordeen SK. HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes[J]. Mol Cancer Res,2010,8(12): 1643-1655. [50]Kron KJ, Liu L, Pethe VV, et al. DNA methylation of HOXD3 as a marker of prostate cancer progression[J]. Lab Invest,2010,90(7): 1060-1067. [51]Nguyen Kovochich A, Arensman M, Lay AR, et al. HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma[J]. Cancer,2013,119(3): 529-539. [52]Marra L, Cantile M, Scognamiglio G, et al. Deregulation of HOX B13 expression in urinary bladder cancer progression[J]. Curr Med Chem,2013,20(6): 833-839. [53]Kocak H, Ackermann S, Hero B, et al. Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma[J]. Cell Death Disease,2013,4: e586. [54]Zhai Y, Kuick R, Nan B, et al. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion[J]. Cancer Res,2007,67(21): 10163-10172. |
[1] | 侯翌葳 杨宇 王博 段英涛 姚宏波. 普兰林肽对5×FAD小鼠和WT小鼠认知行为及脑和视网膜β淀粉样蛋白6E10、炎症因子和神经细胞形态的影响[J]. 解剖学报, 2023, 54(3): 283-288. |
[2] | 王子慧 郭建林 臧夏炎 薛奇杰 林凯琳 张春博 韩璐 林俊堂 徐存拴 . 大鼠肝再生的肝细胞干性变化中性别决定区转录因子2 mRNA和其他非编码RNA的表达变化与作用[J]. 解剖学报, 2023, 54(2): 202-207. |
[3] | 张圆 时萌萌 贺嘉贝 吴琼 钟小林 向宇燕 徐杨 何洁 . 慢性束缚应激对小鼠海马N6甲基腺苷及相关酶表达的影响[J]. 解剖学报, 2023, 54(2): 142-148. |
[4] | 张润恒 杨翠珠 李诗琪 王姝涵 王欣 刘靖 马宇昕. 石菖蒲挥发油对炎性痛大鼠脊髓背角中胶质纤维酸性蛋白、c-Jun氨基末端蛋白激酶和肿瘤坏死因子α表达的影响[J]. 解剖学报, 2023, 54(1): 23-29. |
[5] | 姬光瑜 周娟 李心悦 郝洪波. 多梳家族因子1对结直肠癌干细胞富集的影响及其机制[J]. 解剖学报, 2022, 53(5): 613-619. |
[6] | 卢芬 杨晴 邵文君 孙振坤 王恩漫 张伟娜. 微小RNA-98-5p靶向Kruppel样转录因子9对大鼠心肌缺血再灌注损伤的保护作用[J]. 解剖学报, 2022, 53(3): 347-353. |
[7] | 李伟 杨赣军 彭建安 胡红梅 周星辰. 低氧化应激下肿瘤坏死因子α过表达对牙髓干细胞生物学性能的影响[J]. 解剖学报, 2022, 53(1): 66-74. |
[8] | 谭学明 赵冉 孙永珍 高晓炎 招鹏 王燕 朱敏 李卫东. 超声内镜精准评估肿瘤起源及组织学特征可提高食管平滑肌瘤的手术疗效[J]. 解剖学报, 2021, 52(6): 966-971. |
[9] | 林宝勇 徐进超 应涵韬 蒋欣 刘焕彩 王箐 王巧真 陈燕春. DEAD-box RNA解旋酶5和转录因子12与肌萎缩侧索硬化症的关系[J]. 解剖学报, 2021, 52(5): 698-705. |
[10] | 苏昊 任捷 秦丽华. Nogo-B受体在恶性实体肿瘤发病中的抑制和促进作用[J]. 解剖学报, 2021, 52(3): 489-494. |
[11] | 许晨 胡雪峰. 上腭发生的分子调控机制[J]. 解剖学报, 2021, 52(2): 317-322. |
[12] | 邹琳清 衣昕 何辉 单柏权 金国华 李浩明 . 海马去神经支配损伤后放射状胶质细胞表达RUNX1T1的变化及向神经元分化的影响[J]. 解剖学报, 2020, 51(6): 809-814. |
[13] | 阴雪妍 郭哨恺 谭军 范文统 李明. 腺苷预处理对大鼠脑缺血-再灌注损伤后脑内肿瘤坏死因子α和核因子κB表达的影响[J]. 解剖学报, 2020, 51(6): 839-847. |
[14] | 吴邢 檀梦天 覃晓莉 洪艳. 神经元素3基因沉默对脐源性胰岛前体细胞MafA表达的影响[J]. 解剖学报, 2020, 51(5): 758-764. |
[15] | 林晨 马琪 王萍 . 冠蛋白:肿瘤诊断的潜在靶点[J]. 解剖学报, 2020, 51(3): 461-468. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||