解剖学报

›› 2009, Vol. 40 ›› Issue (2): 312-316.doi: 10.3969/j.issn.0529-1356.2009.02.029

• 论著 • 上一篇    下一篇

低剂量棉酚与甾体激素联合用药抗男性生育协同作用

常青 ;邵金辉; 许增禄*; 张成侠; 钱晓菁   

  1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 人体解剖学与组织胚胎学系，北京 100005
  • 收稿日期:2008-11-11 修回日期:2008-12-08 出版日期:2009-04-06
  • 通讯作者: 许增禄

Synergistic effect of combined regimen of low-dose gossypol with steroid hormones on male antifertility

  1. Department of Anatomy，Histology and Embryology， Institute of Basic Medical Sciences，Chinese Academy of Medical Sciences， School of Basic Medicine，Peking Union Medical College， Beijing 100005，China
  • Received:2008-11-11 Revised:2008-12-08 Online:2009-04-06
  • Contact: XU Zeng-lu

关键词: 棉酚, 甾体激素, 抗男性生育, 协同作用, 大鼠

Abstract: Objective To study the synergistic effect on male antifertility of a combined regimen of lowdoes gossypol with steroid hormones. Methods Adult male rats were divided randomly BR> into four groups: group GH, rats were fed orally with GA ［12.5mg/(kgI>&#/I>8226;d)］ and DSG ［0.125mg/(kgI>&#/I>8226;d)］/E ［0.025mg/(kgI>&#/I>8226;d)］/TU［100mg/L(kgI>&#/I>8226;d)］; group G, a single does of GA ［12.5mg/(kgI>&#/I>8226;d)］ was given; group H, DSG ［0.125mg/(kgI>&#/I>8226;d)］/E［0.025mg/(kgI>&#/I>8226;d)］/TU［100mg/(kgI>&#/I>8226;d)］ were administered; group C, rats only received vehicle (1% methyl cellulose). The testis and epididymis were removed at 4,6 and 8 week for counting sperm number，sperm motility and stereological changes of testis tissue. Results Low-dose gossypol with steroid hormones did not have a synergistic effect on reducing testicular weight，sperm production or stereological parameters. However, they did have a synergistic effect on reducing epididymal sperm number and sperm motilit

Key words: Gossypol, Steroid hormone, Male antifertility, Synergistic effect, Rat

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